W-H NORMAL L -V V 4 >-Q 200 n 3 160 w 120 2 80 I -0 5 10 15 20 25 t P FIG. 1 . Trypsin, invertase and amylase content of feces of germ free, ex-germfree and conventional rats.,4t P germfree animals were infected with sporeforming bacteria from the cecum of a conventional animal and at TF with suspension of feces from conventional rats.Amylase content of the feces in the germfree rats was the same or slightly higher than that of the conventional rats. The occurrence of invertase in the feces of germfree animals agrees with the finding of carbohydrases in intestinal extracts from germfree rats(8).Allcr infection of the g,rcrmfrw aniinals with \powforining hacxteria from the cecum content of a convcntiorial animal, tio decrease occurred in the enzymatic contents of the feces but rather sharp fluctuations were noticed in invertase and trypsin activity. This might be connected with the diarrhea that is a constant symptom in infection of germfree animals with certain intestinal bacteria. After superinfection with full intestinal flora of the conventional animals, tryspin content of the feces decreased to the zero values of the conventional rats within 24 hours.Conclusions. Results indicate that autodigestion is not the main pathway for normally occurring inactivation of trypsin and invertase. The results infer that one or several of the normal microbiological inhabitants of the intestines are responsible for normally occurring inactivation of the digestive enzymes of intestinal contents.
Paronychia granulomatosa is a complication incident to unguis incarnatus; surgery for this complaint was performed on 26 patients with 52 granulomas. The operation was first described by Bartlett in 1937. The postoperative hospitalization was 3 days and the patients returned a week later to have the sutures removed. After the operation, ten remaining granulomas were observed of which 6 were cured by operation and 2 conservatively, leaving 2 under continuing conservative treatment (5 months and 1 month, respectively).
A 62-year old man who presented unwell with no specific symptoms or signs was found to have portal venous circulation gas complicating a small diverticular abscess. He was successfully managed with a course of antibiotics and had full resolution of symptoms, therefore avoiding the need for surgical intervention. While most commonly associated with bowel ischaemia and therefore often warranting emergency laparotomy, portal venous gas within the context of other underlying pathology often presents opportunities for delayed surgery or more conservative management options.
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