Renal involvement in Systemic Lupus Erythematous (SLE) patients is one of the leading causes of morbidity and a significant contributor to mortality. It’s estimated that nearly 50% of SLE individuals develop kidney disease in the first year of the diagnosis. Class IV lupus nephritis (LN-IV) is the class of lupus nephritis most common in Colombian patients with SLE. Altered miRNAs expression levels have been reported in human autoimmune diseases including lupus. Variations in the expression pattern of peripheral blood circulating miRNAs specific for this class of lupus nephritis could be correlated with the pathophysiological status of this group of individuals. The aim of this study was to evaluate the relative abundance of circulating microRNAs in peripheral blood from Colombian patients with LN-IV. Circulating miRNAs in plasma of patients with diagnosis of LN-IV were compared with individuals without renal involvement (LNN group) and healthy individuals (CTL group). Total RNA was extracted from 10 ml of venous blood and subsequently sequenced using Illumina. The sequences were processed and these were analyzed using miRBase and Ensembl databases. Differential gene expression analysis was carried out with edgeR and functional analysis were done with DIANA-miRPath. Analysis was carried out using as variables of selection fold change (≥2 o ≤-2) and false discovery rate (0.05). We identified 24 circulating microRNAs with differential abundance between LN-IV and CTL groups, fourteen of these microRNAs are described for the first time to lupus nephritis (hsa-miR-589-3p, hsa-miR-1260b, hsa-miR-4511, hsa-miR-485-5p, hsa-miR-584-5p, hsa-miR-543, hsa-miR-153-3p, hsa-miR-6087, hsa-miR-3942-5p, hsa-miR-7977, hsa-miR-323b-3p, hsa-miR-4732-3p and hsa-miR-6741-3p). These changes in the abundance of miRNAs could be interpreted as alterations in the miRNAs-mRNA regulatory network in the pathogenesis of LN, preceding the clinical onset of the disease. The findings thus contribute to understanding the disease process and are likely to pave the way towards identifying disease biomarkers for early diagnosis of LN.

INTRODUCTION: The reflection about the elements of communication that health professionals use strengthens the empathic relationship and therefore the actions that seek self-care in patients. Nursing schools must teach how to acquire competences from what should be (moral) to fully consider the emotions and needs of hospitalized children so that they can attend to the call of care. Nursing should tend to social and communication skills to offer a humanized care when children appeal to crying, to silence, to play, to attract attention. OBJECTIVE: Propose a framework of moral management of communication from the design of a functional communication structure model for the pediatric patient to come to the call of their care in a positive way. METHODOLOGY: Nature of qualitative study of descriptive type and symbolic interactionism (perceptual regression). The population was 44 nurses. The data was obtained by interviews analyzed by the STATGRAPHICS XVII Centurión Plus® and Atlas Ti 8.0 ® programs. CONCLUSION: The practices of nurses respond to the dynamics so that the child comes to the care when they are aware of the purpose of communication in strengthening the moral development of the child. A model of functional communication structure for pediatric patient care adjusted to the axioms of Paul Watzlawick is proposed.

Introducción: Adolescentes y adultos jóvenes participan frecuentemente en comportamientos sexuales riesgosos (relaciones sexuales sin protección, sexo con parejas casuales, promiscuidad, iniciación sexual temprana, etc.), trayendo consigo embarazos no planeados, Infecciones de Transmisión Sexual, suicidios, abortos, afectaciones académicas y laborales. El objetivo del estudio, fue identificar los comportamientos sexuales riesgosos y factores asociados en estudiantes de una universidad en Barranquilla, 2019. Materiales y métodos: Estudio de tipo descriptivo-correlacional de corte transversal, se utilizó la Encuesta de Riesgo Sexual, que evaluó comportamientos sexuales riesgosos en universitarios de Barranquilla, en los últimos seis meses, se generaron los coeficientes de correlación Chi cuadrado de Pearson (nivel de confianza 95%; p≤0.05) para medir la asociación entre los puntajes de riesgo sexual y factores sociodemográficos y académicos. Resultados: El 63% de los participantes inició actividad sexual antes de los 18 años. 87% han participado una o más veces en comportamientos sexuales de riesgo: sexo vaginal sin condón (73%), fellatio sin condón (60.3%), número de parejas con quién tienen comportamientos sexuales (66.2%) y experiencias sexuales inesperadas (54.4%). Los hombres y estudiantes de Derecho tenían puntajes de riesgo sexual más altos que las mujeres y los estudiantes de Enfermería. Conclusión: Los universitarios están en riesgo y participando en comportamientos sexuales riesgosos, que podrían afectar su salud y proyecto de vida. Los factores de mayor riesgo fueron; sexo temprano, género, edad >20 años, prácticas sexuales arriesgadas como el sexo vaginal, oral y anal sin protección y conductas sexuales impulsivas y no planificadas. Introduction: Adolescents and young adults are frequently involved in risky sexual behavior (unprotected sex, sex with casual partners, promiscuity, early sexual initiation, etc.) bringing with them, unplanned pregnancies, sexually transmitted infections, suicides, abortions, academic and labor affectations. The objective of the study was to identify risky sexual behaviors and associated factors in students at a university in Barranquilla, 2019.Materials and methods: Study descriptive-correlational cross-sectional, the sexual risk survey was used, which evaluated risky sexual behavior in university students of Barranquilla in the last six months, were generated correlation coefficients Chi-square Pearson (95% confidence level; p≤0.05) to measure the association between sexual risk scores and sociodemographic and academic factors.Results: 63% of participants initiated sexual activity before the age of 18. The 87% have participated one or more times in risky sexual behaviors: vaginal sex without a condom (73%), fellatio without a condom (60.3%), number of partners with whom they have sexual behaviors (66.2%) and unexpected sexual experiences (54.4%). Men and law students had higher sexual risk scores than women and nursing students.Conclusion: The university students are at risk and participating in risky sexual behavior, which could affect their health and life Project. The major risk factors were; early sex, gender, age >20 years, risky sexual practices such as vaginal, oral, and anal unprotected sex and impulsive and unplanned sexual behaviors.

Background Informed consent is an important factor in a child’s moral structure from which different types of doctor–patient relationships arise. Children’s autonomy is currently under discussion in terms of their decent treatment, beyond what doctors and researchers perceive. To describe the influential practices that exist among clinicians and researchers toward children with chronic diseases during the process of obtaining informed consent. Methods This was a cross-sectional, qualitative study via a subjective and interpretivist approach. The study was performed by conducting semi-structured interviews of 21 clinicians and researchers. Data analysis was performed using the SPSS version 21® and Atlas Ti version 7.0® programs. Results The deliberative and paternalistic models were influential practices in the physician–patient relationship. In the deliberative model, the child is expected to have a moral awareness of their care. The paternalistic model determined that submission was a way of structuring the child because he or she is considered to be a subject of extreme care. Conclusions The differentiated objectification [educational] process recognizes the internal and external elements of the child. Informed consent proved to be an appropriate means for strengthening moral and structuring the child.

Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

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INTRODUCTION: The obstetirc or noenatal risk factors, are in many cases the major evidence to define and forecast of an early neonatal sepsis, considering that a newborn that has lived less tan 72 hours presents unspecified clinical manifestations and the diagnostic exams utilize infectious and inflammatory markers, with there being very litttle scientific evidence to support and establish an early diagnosis. Objective: Associate the obstetric and neonatal risk factors with the presence of early sepsis in Cartagena. MATERIALS & METHODS: A retrospective study of cases and controls was conducted. The sample consisted of 183 cases and 366 controls, including pacients who met simultaneously inclusion and exclusion criteria. A bivariated analysis and a multivariated model of regression logistics were used. RESULTS: Among the associtated variables and early sepsis in which it was able to define the risk that is found when there is a premature membrane rupture > 18 hours (OR 9,57 IC 95% 4,12-22,26), premature newborn (OR 8,19 IC 95% 3,66-18,3), the presence of maternal fever (OR 6,49 IC 95% 3,43-12,3), marital status (OR 5,89 IC 95% 3,42-10,15) and level of education (OR 4,80 IC 95% 2,63-8,77). CONCLUSIONS: The mechanisms of fetal evaluation and maternal prophylaxis should be prioritized in the cases of pregnant women that present a premature membrane rupture >18 hours, and have kids who were born premature and living in couple with a low level of education.

ORIGINAL Infection by ABSTRACT.Objective. Determine the prevalence of infection by Ehrlichia canis and Anaplasma sp. and its correlation with epidemiological and laboratory aspects, in dogs treated in veterinary clinics in Barranquilla, Colombia. Materials and methods. Retrospective, descriptive cross-sectional study. The data was obtained between the months from January to August 2015. 184 dogs that clinically presented the infection with these agents were studied. Criteria for positivity were immunochromatography kit and blood smear, epidemiological and laboratory data. Results. Global prevalence was ascertained as 34% (63 dogs), 28% (52/184 dogs) for E. canis and 6% (11/184 dogs) to Anaplasma sp. Hemogram of dogs infected with both bacteria were hematocrit decreased, they also showed leukopenia and thrombocytopenia. Conclusions. Findings reported in this study show a high prevalence and endemicity of E. canis y Anaplasma sp. in Barranquilla when compared with other colombian regions. Hemogram findings showed to be relevant to diagnostic and prognostic of these infectious diseases.