A solid-phase route for the preparation of 2-aminoimidazolones has been developed which can incorporate diverse functionality at each
position of the molecule. Resin-bound S-methyl isothioureas were converted to structures of type I by using commercially available Fmoc-protected amino acids. Products of structure II were accessed by reaction of the S-methyl isothiourea with 5-substituted oxazolones.
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