The protective effect of the polysaccharides on ethylene glycol induced kidney impairment has been explored. Polysaccharides have been extracted from Sargassum graminifolium, which belongs to brown algae. Three different doses of polysaccharides were used for rats with kidney stones by ethylene glycol feeding. Then, urinary biochemistry parameters, renal function factors including blood urea nitrogen (BUN) and serum creatinine (Scr) levels were detected. Besides, interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) in kidney tissue were elevated, which belong to proinflammatory cytokines. Moreover, kidney histopathological sections were examined. The results illustrated that polysaccharides not only increased calcium level but also decreased oxalate, Scr, and BUN levels. In addition, the levels of IL-6 and TNF-α were reduced. Moreover, renal microscopic analysis showed polysaccharides treatment alleviated observably calcium oxalate deposits in the kidney tissue. The results indicated that the renoprotective mechanism of SGP may be attributed to suppression of inflammation, reducing the growth of urinary stones and improving kidney function in vivo, which explained SGP through multiple ways to protect kidney cells from damaging of hyperoxaluria rats.
Bletilla striata (Thunb.) Reichb.f. is a species of genus Bletilla (Family Orchidaceae) and it is a commonly used traditional Chinese medicine. Bletilla striata polysaccharides (BSPs) were extracted from the tuber of Bletilla striata. Herein, we reviewed the extraction and purification methods of BSPs, compared the advantages and disadvantages of different methods comprehensively, and analyzed molecular weights and structural characterization of BSPs systematically. In addition, we analyzed hemostasis, anti-oxidation, anti-aging and other functional activities of BSPs to provide scientific basis for further study of BSPs.
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