During a programme of work directed at developing a manufacturing route for SB 214857, Lotrafiban, the need arose to find methodology for efficiently destroying hydrogen peroxide in aqueous solutions of the penultimate intermediate, SB 270051.Whilst this was initially achieved using a chemical process, a biotransformation process has now been developed that utilises a polymer-supported catalase enzyme to remove peroxide from reaction mixtures. The biocatalytic approach provides an economic and environmentally friendly solution to peroxide removal when compared to the chemical process.
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