The case of a child affected with neuroblastoma, ganglioneuroma and neurofibromatosis is reported. Germinal mutation is probably the cause of this coincidence. In view of the dominant inheritance of neurofibromatosis and of pheo‐chromocytoma, the inference is made that neuroblastoma generally may be attributable to a dominant mutation which in the past has been lethal, but which, as a result of therapeutic progress, may be inherited by the offspring of survivors in the future, as has been noted for retinoblastoma.
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