Background The COVID-19 pandemic imposed a great burden on every healthcare sector including primary care. Confident clinical decisions, proactive isolation of suspicious cases, and testing resource allocation are of crucial importance at primary care facilities. The criterion standard for the diagnosis of COVID-19, a multisystem disease with diverse symptoms, is real-time reverse-transcription polymerase chain reaction (rRT-PCR). Objectives We aim to identify clinical and demographic predictors of a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rRT-PCR test result at a single primary care facility in Greece. Methods A single-center retrospective cross-sectional study was carried out from October 22 to November 23, 2020, investigating various characteristics of individuals presenting at a primary care facility for rRT-PCR testing for the detection of SARS-CoV-2. Logistic regression was performed to identify clinical and demographic predictors of a positive rRT-PCR test result for the detection of SARS-CoV-2. Results A total of 118 specimens were included in the study, corresponding to 118 individuals, whose median age was 43.5 years (interquartile range, 28 years). Most of the participants were symptomatic (69.5%; n = 82), with fever (40.7%; n = 48), cough (21.2%; n = 25), and nasal congestion/discharge (16.9%; n = 20) being the most common presenting symptoms. The probability of a positive SARS-CoV-2 rRT-PCR result was greater for patients presenting with fever (odds ratio [OR], 10.631; 95% confidence interval [CI], 2.402–47.055; P = 0.002), anosmia or ageusia (OR, 9.56; 95% CI, 1.481–61.704; P = 0.018), and nasal congestion or discharge (OR, 7.138; 95% CI, 1.329–38.353; P = 0.022), compared with patients without. Conclusions The presence of fever, anosmia or ageusia, and nasal congestion or discharge may successfully predict a positive SARS-Cov-2 rRT-PCR test result at primary care settings.
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