The current paper discusses a key area in the development of novel biobased products used in the food, cosmetics, and pharmaceutical sectors. Herein, we made a conscious effort to conduct research on the optimal rose flower wax (RFW) gelation concentration to promote wheat germ oil (WGO) gelation because both components of this contribution have beneficial impacts on human health. The critical gelation concentration of RFW required to bring about gelation of WGO was oleogel (OG) 9% (w/w). The alterations in the characteristic features of RFW and WGO were thoroughly examined at the macroscopic and microscopic levels. Images taken with bright field and polarized light microscopes revealed the crystalline network structure of fiber-like fat crystals. The Fourier transform infrared and micro-Raman data indicate that the interactions between the constituent parts of OGs were composition-dependent. X-ray diffraction diffractograms reveal the presence of a metastable β′ polymorphic form of fat crystal in the OGs. Furthermore, the development of solid fat crystals in OG compositions was used by the crystallization kinetics to explain the rate of OG crystallization. According to mechanical tests, OG 17.5 considerably has the highest firmness (F 0) and work of shear (C 0) abilities, indicating that it has greater mechanical strength, molecular interaction, and stability than the other OG formulations. The in vitro drug (curcumin) release from the synthesized OGs was modeled using the Korsmeyer–Peppas equation, and the results suggested that the drug molecules diffused out of the OGs through a non-Fickian mechanism. The OGs demonstrate the ability to be explored for oral drug delivery applications.

Oleogels (OGs) have gained a lot of interest as a delivery system for a variety of pharmaceuticals. The current study explains the development of jasmine floral wax (JFW) and wheat germ oil (WGO)-based OGs for oral drug (curcumin) delivery application. The OGs were made by dissolving JFW in WGO at 70 °C and cooling it to room temperature (25 °C). The critical gelation concentration of JFW that induces the gelation of WGO was found to be 10% (w/w). The OGs were characterized using various techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), microscopic analysis, and mechanical test. XRD data indicated that JFW influences the crystallinity of the OGs. Among the prepared OGs, OG 17.5 showed higher crystallization in the series. Optical microscopic studies demonstrated the formation of fiber structures due to the entanglement of crystals whereas, polarized light micrographs suggested the formation of spherulites or clustered crystallite structures. The mechanical properties of the OGs increased linearly with the increase in the JFW concentration. Curcumin-loaded OGs were examined for their controlled release applications. In summary, the developed OGs were found to have the necessary features for modulating the oral delivery of curcumin.

Measurement of temperature one of the most important parameters for a wide range of applicatoins, including biological and chemical systems, because it effects cellular activity by controlling metabolic processes within...

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