No abstract

BackgroundThe lives of half a million children in the United States are severely affected due to the alterations in their functional and mental abilities which epilepsy causes. This study aims to introduce a novel decision support system for the diagnosis of pediatric epilepsy based on scalp EEG data in a clinical environment.MethodsA new time varying approach for constructing functional connectivity networks (FCNs) of 18 subjects (7 subjects from pediatric control (PC) group and 11 subjects from pediatric epilepsy (PE) group) is implemented by moving a window with overlap to split the EEG signals into a total of 445 multi-channel EEG segments (91 for PC and 354 for PE) and finding the hypothetical functional connectivity strengths among EEG channels. FCNs are then mapped into the form of undirected graphs and subjected to extraction of graph theory based features. An unsupervised labeling technique based on Gaussian mixtures model (GMM) is then used to delineate the pediatric epilepsy group from the control group.ResultsThe study results show the existence of a statistically significant difference (p < 0.0001) between the mean FCNs of PC and PE groups. The system was able to diagnose pediatric epilepsy subjects with the accuracy of 88.8% with 81.8% sensitivity and 100% specificity purely based on exploration of associations among brain cortical regions and without a priori knowledge of diagnosis.ConclusionsThe current study created the potential of diagnosing epilepsy without need for long EEG recording session and time-consuming visual inspection as conventionally employed.

No abstract

This study introduces a new approach for assessing the effects of pediatric epilepsy on a language connectome. Two novel data-driven network construction approaches are presented. These methods rely on connecting different brain regions using either extent or intensity of language related activations as identified by independent component analysis of fMRI. An auditory word definition decision task paradigm was used to activate the language network for 29 patients and 30 controls. Evaluations illustrated that pediatric epilepsy is associated with a network efficiency reduction. Patients showed a propensity to inefficiently use the whole brain network to perform the language task; whereas, controls seemed to efficiently use smaller segregated network components to achieve the same task. To explain the causes of the decreased efficiency, graph theoretical analysis was performed. The analysis revealed substantial global network feature differences between the patients and controls for the extent of activation network. It also showed that for both subject groups the language network exhibited small-world characteristics; however, the patient's extent of activation network showed a tendency toward randomness. It was also shown that the intensity of activation network displayed ipsilateral hub reorganization on the local level. We finally showed that a clustering scheme was able to fairly separate the subjects into their respective patient or control groups. The clustering was initiated using local and global nodal measurements. Compared to the intensity of activation network, the extent of activation network clustering demonstrated better precision. This ascertained that the network differences presented by the networks were associated with pediatric epilepsy.

No abstract

The large data size and dimensionality of hyperspectral data demands complex processing and data analysis. Multispectral data do not suffer the same limitations, but are normally restricted to blue, green, red, red edge, and near infrared bands. This study aimed to identify the optimal set of spectral bands for nitrogen detection in grape leaves using ensemble feature selection on hyperspectral data from over 3,000 leaves from 150 'Flame Seedless' table grapevines. Six machine learning base rankers were included in the ensemble: random forest, LASSO, SelectKBest, ReliefF, SVM-RFE, and chaotic crow search algorithm (CCSA). The pipeline identified less than 0.45% of the bands as most informative about grape nitrogen status. The selected violet, yellow-orange, and shortwave infrared bands lie outside of the typical blue, green, red, red edge, and near infrared bands of commercial multispectral cameras, so the potential improvement in remote sensing of nitrogen in grapevines brought forth by a customized multispectral sensor centered at the selected bands is promising and worth further investigation. The proposed pipeline may also be used for application-specific multispectral sensor design in domains other than agriculture.

No abstract

No abstract