Background: In endodontic therapy, final irrigation is often done with sodium hypochlorite (NaOCl). This jeopardizes the bond strength between the epoxy resin sealer, used subsequently in obturation and radicular dentin. This study aimed to analyze the effect of natural antioxidants, 6.5% proanthocyanidin (PA) and 25% bamboo salt (BS) on the reversal of NaOCl-induced reduced bond strength of an epoxy resin sealer to dentin. Materials and Methods: Thirty-three single-rooted extracted human teeth were randomly divided into three groups based on the final irrigation protocol: group 1 (saline), Group 2 (6.5% PA), and Group 3 (25% BS). The canals were cleaned, shaped, and obturated with gutta-percha and AH Plus sealer. 1.5 mm-thick root slices made from coronal, middle, and apical thirds of the canal were subjected to push-out bond strength (PBS) testing. The data were statistically analyzed using Kruskal–Wallis and Dunn's post hoc test ( P < 0.05). Results: 5.25% NaOCl significantly decreased the bond strength of AH Plus to dentin ( P < 0.05). Both 6.5% PA and 25% BS were capable of reversing the compromised PBS of AH Plus to NaOCl-treated dentin. Conclusion: Final irrigation with antioxidants such as PA and BS eliminates the risk of reduced bond strength of AH Plus to root canal walls, which ensues following the use of NaOCl as an irrigant.