Background:Topical steroids remain the mainstay of treatment in eczema, an inflammatory skin reaction characterized by pruritus, redness, scaling, and clustered oozing papulovesicles. Halometasone is a new potent corticosteroid approved in the Indian market for topical application in the treatment of dermatitis.Aims:To evaluate the efficacy and safety of halometasone in the treatment of acute or chronic noninfected eczematous dermatosis in Indian population.Materials and Methods:A prospective, open, multicentric, phase 3, noncomparative clinical trial conducted at outpatient departments of seven centres. Two hundred endogenous eczema patients meeting study criteria were enrolled. Halometasone 0.05% cream was applied twice daily for 30 days in chronic and 20 days in acute eczema patients. Calculation of eczema area and severity index, and assessment of investigator's global assessment of severity of eczema and severity of pruritus score were done at each visit and compared with baseline. All adverse events (AE) were captured and documented. Laboratory investigations including haematological tests, urinalysis, renal and liver function tests were performed at baseline and at end of treatment.Results:Of the 200 patients enrolled, 180 were chronic and 20 were acute eczema patients. It was found that there was a significant (P<0.001) improvement in all efficacy parameters compared with baseline. The treatment was shown to be successful in 91% patients. AE were reported in 30 patients and there was no serious AE reported. There was no clinically significant difference in laboratory investigations with treatment.Conclusions:Halometasone was shown to be safe and very effective in Indian patients with acute and chronic eczema and the drug was well tolerated.
Forty genotypes of chickpea were evaluated for assessing genetic divergence for different quantitative characters for improving yield potential of chickpea by using Mahalanobis D2 statistics. The genotypes were grouped into
seven clusters suggesting considerable amount of genetic diversity in the material. The intra-cluster D2 value ranged from 0.00 to 9.06 while, intercluster D2 value ranged from 4.07 to 55.71. The maximum intra cluster distance was exhibited by
cluster V followed by cluster II and cluster I. Cluster III had mono- genotype and emerged with contained highest cluster mean value grain yield per plot. Cluster II has highest mean value for number of pods per plant and lowest mean value for days
to 50% flowering, days to maturity and plant height. Maximum contribution toward the total divergence was exhibited by 100-seed weight followed by number of pods per plant and minimum by days to maturity. Cluster IV and VI showing maximum inter
cluster distance and crossing of genotypes Sabour chana-1 (BRC-1), GCP 105, PBC 503, DC 16-2, NBeG 776, RVSSG 42, G2016-43, GL 14042, IPC 2013-21, GNG 2338, GNG 2375 and KWR 108 from cluster VI suggested for improving grain yield per plot, 100-seed
weight and earliness in flowering and ultimately enhancing the yield and chances of getting better recombinants in segregating generations.
Migration, a worldwide phenomenon, has often been seen as beneficial for both the sending and receiving countries. However, post-9/11, the phenomenon is seen as a mixed blessing. It is also being realised that it is impossible to check illegal migration unless the sending country cooperates. In South Asia, India has been at the receiving end of the problem of illegal immigration from Bangladesh. This paper argues that such illegal migration is posing a threat to internal security because the issue has not been properly securitised. Migrants seem to have successfully bypassed legal hurdles, which has kept certain territories out of reach even for Indian nationals. If Bangladesh's internal politics and economic deprivation are major factors for this state of affairs, then permissiveness towards illegal immigration in Indian political circles is also responsible. The largely lenient political class has been prompted to take a close look at the issue as an increasing number of Bangladeshis have of late been found to be involved in terror activities.
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