HighlightsMelanoma skeletal muscle metastasis (MSMM) are exceptional.Despite all new advances in melanoma therapy, cure for most MSMM is still elusive.This is the third case of an isolated metastasis of melanoma to the rectus abdominis muscle published in the literature.Radical compartmental surgery should be considered for selected stage IV melanoma patients, with isolated rectus abdominis MSMM, whose disease could be amenable to complete resection, in order to extend median survival.Nowadays, the use of synthetic meshes seems to be one of the best choices for repairing the abdominal wall defect.
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