ZSM-5 has been modified as supported sulfuric acid (ZSM-5-SO 3 H) and introduced for the first time as a mild, convenient, reusable, and heterogeneous catalyst. Various types of aldehydes were efficiently converted to their 1,1-diacetates using a catalytic amount of ZSM-5-SO 3 H in excellent yields under solvent-free and heterogeneous conditions at room temperature. The deprotection of 1,1-diacetates has also been achieved using this novel catalyst in ethanol. The procedure is operationally simple, environmentally benign, and only a stoichiometric amount of anhydride is used.
A KIT-6/poly(acrylic acid-ethylene glycol dimethacrylate) (KIT-6/Poly(AA-EGDMA) nanocomposite was synthesised as an adequate carrier. KIT-6 as a three-dimensional cubic symmetric structure was prepared by the sol-gel method. Polymerisation was carried out through the in situ method in which EGDMA was cross-linked by AA inside KIT-6 pores. This mesostructure acts as a smart uptake and release of the ibuprofen (IBU) system. Diverse characterisation techniques including Fourier transform infrared spectroscopy, X-ray powder diffraction, Brunauer-Emmett-Teller, thermal gravimetric, scanning electron microscopy and ultraviolet-visible spectroscopy were employed to determine the relationship between the carrier nature and drug release performance. The KIT-6/Poly(AA-EGDMA) was modified by changing the ratio of the polymer and IBU as well as its time-loading. The results proved that the KIT-6/Poly(AA-EGDMA) has the ability of drug adsorption and slow release in a simulated body fluid.
Synthesis and Deprotection of 1,1-Diacetates under Eco-Friendly Conditions. -The acylation of aliphatic (I) and aromatic aldehydes (IV) with acetic anhydride proceeds smoothly in the presence of the zeolite ZSM-5-supported sulfuric acid under solvent-free, heterogeneous conditions at room temperature. Deprotection of the acetals (III) and (V) also occurs efficiently by using the same catalyst. The procedure is simple, environmentally benign, and only a stoichiometric amount of the acylating agent is required. -(MASSAH*, A. R.; KALBASI, R. J.; SHAFIEI, A.; Monatsh. Chem. 143 (2012) 4, 643-652, http://dx.
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