A new ligand of 1,2,4-triazole derivative was produced by cyclization of sodium dithiocarbamate derivative of ethyl 4-ethoxy-3-nitrobenzoate with carbon disulfide in an alkaline medium. The new ligand, entitled name: L: 4-amino-5-(3-ethoxy-5-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione, was fully characterized depending on HPLC-MS, FTIR, 1H-NMR and 13C-NMR spectroscopies. In addition, the elemental microanalysis was carried out to confirm the skeletal structure of the ligand L. A library of complexes with Ni(II), Zn(II), Pd(II), and Pt(IV) metal ions was prepared by coordination with the ligand. These complexes were characterized by using FTIR, UV-Ѵis, 1H-NMR, 13C-NMR, spectrophotometric techniques, elemental analysis C.H.N.S, and FAAS. The physicochemical properties of these complexes were determined at 25 °C, such as melting point, magnetic susceptibility and molar conductivity. The microbial study confirmed that the novel ligand and its complexes have the potential to be applied as antimicrobial agents.
Two Schiff bases, namely, 3-(benzylidene amino) -2-thioxo-6-methyl 2,5-dihydropyrimidine-4(3H)-one (LS])and 3-(benzylidene amino)-6-methyl pyrimidine 4(3H, 5H)-dione(LA)as chelating ligands), were used to prepare some complexes of Cr(III), La(III), and Ce(III)] ions. Standard physico-chemical procedures including metal analysis M%, element microanalysis (C.H.N.S) , magnetic susceptibility, conductometric measurements, FT-IR and UV-visible Spectra were used to identify Metal (III) complexes and Schiff bases (LS) and (LA). According to findings, a [Cr(III) complex] showed six coordinated octahedral geometry, while [La(III), and Ce(III) complexes]were structured with coordination number seven. Schiff's bases and mineral complexes were examined in vitro to investigate potential inhibition against Gram-positive bacteria such as Pseudonomous aerugionosa and Gram-negative bacteria such as Staphylococcus aureus. The low concentration for inhibition has been also determined by studying the minimal inhibitory concentrations MIC .Antibiotics (Ampicillin, Amoxicillin) have been chosen to contrast their activity. Furthermore, Anti-fungal activity against two types of fungi ʺAspergillus flavusʺ and ʺPenicillum Spp.ʺ was studied for these compounds. The results of the antibacterial activity were better compared to the standard drugs.
In this study, new substituted 2-amino-3-cyanopyridine derivatives were synthesized in excellent yields by reacting chalcone derivatives with malanonitrile in the presence of ammonium acetate, and new complexes with these ligands were synthesized and characterized by elemental analysis, UV, IR, Mass, and NMR (1H, 13C) spectroscopy, and had the general formula: [ML2(H2O)2]Cl2 where M= Co(ІІ), Ni(ІІ) and Cu(ІІ), [ML2(H2O)Cl]Cl2 where M= Cr (ІІІ). On the basis of analytical data and IR studies, a 1:2 metal to ligand stoichiometry has been suggested to these coordination complexes. All of these studies suggest that the ligand acted as a bi-dentate ligand when it coordinates with metal ions, and that the prepared complexes had an octahedral geometry coordinated by both the nitrogen of (cyano group) and (amino group). The ligand and its complexes were tested for antimicrobial activity against gram negative (Pseudonomous aeruginosa) and gram positive (Bacillus subtitis) bacteria. All of these complexes have been shown to be more antibacterial than their respective ligands.
The 1,2, 3-triazole moiety is the main biomolecule formed from the chemistry of clicks. Click chemistry is cycloaddition reaction including Copper or ruthenium catalyzed with azide-alkyne and resulting in five membered rings. Click chemistry and its complexes are utilized as anti-cancer, anti-microbial, anti-tuberculosis, anti-viral, anti-diabetic, anti-malarial, ant?-leishmanial and neuroprotective agents and also in fluorescent technology. Biological targets required a method containing the linker feature like 1,2, 3-triazoles moiety and a new set of 1,2,3-triazole consisting hybrids and conjugates. The present review summarizes developments over the last few years in application complexes of 1,2, 3-triazole analogue. Scientists of organic fields, clinical chemistry, photochemistry, and pharmacology will benefit from this study. This review offers essential knowledge to the interested researchers.
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