This paper focuses on the generation of synthetic models of water distribution networks (WDN). Models are widely used in many fields related with WDN planning and operation. Therefore, the main contribution of this work is to provide an automatic procedure to build models with the well-known EPANET tool in a manner that, with a small amount of input data and a few clicks, the user can build a network topology and assign suitable pipe diameters. For that purpose, a new application, called WaterNetGen, was designed and implemented as an extension to the EPANET software. WaterNetGen can be used to generate synthetic models of WDN, with several hundred nodes and pipes, within a few minutes. The sizing capability allows the selection of commercial diameters, such that the final network design satisfies certain user-defined design constraints, like minimum diameter, maximum velocity and minimum pressure. The total water demand is allocated to the pipes taking into account their length and a demand coefficient. The water demand of each pipe is then assigned to its start and end nodes and follows a specific demand pattern.

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BACKGROUND: Most studies concerning intraoperative temporary arterial occlusion overlook the period between and after clip placement. OBJECTIVE: To analyze the brain tissue oxygen tension through the process by which anterograde arterial blood flow is re-established after temporary clipping (TR). METHODS: In this prospective observational study, patients who presented to surgery for middle cerebral artery aneurysms were continuously monitored with ICM+, to obtain temporal (downstream) P bt O 2 levels while M1 segment temporary clips were applied and removed. P bt O 2 changes were analyzed and compared with the clipping phase, and measures of exposure to hypoxia were defined and assessed during both phases and used in a model to test the impact of extending them. RESULTS: Eighty-six TRs (20 patients) were recorded. The mean acquired amount of time per clip release (CR) event was 336.7 seconds. Temporary clip removal produced specifically shaped, highly individual P bt O 2 curves that correlated with their corresponding clipping phase events but developing slower and less consistently. The CR phase was responsible for greater cumulative exposure to hypoxia than the clip application phase through the first and second minutes of each. In our model, the duration of the TR phase was mostly responsible for the total exposure to hypoxia, and longer CR phases reduced the mean exposure to hypoxia. CONCLUSION: During the clip removal phase, the brain tissue is still exposed to oxygen levels that are significantly below the baseline, reverting through a singular, dynamic process. Therefore, it must be regarded by surgeons with the same degree of attention as its counterpart.

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