Psychotropics are among the most prescribed medications. There are indications in the literature that fluoxetine (FLX; selective serotonin reuptake inhibitor [SSRI] antidepressant) and methylphenidate (MPH) could have a hormonal mode of action. This study was designed to evaluate the immature rat uterotrophic assay Substitute by (1) if sertraline (SER) and escitalopram (ESC) 2 other SSRI antidepressants would share the estrogenicity described for FLX and (2) MPH for estrogenicity and antiestrogenicity. The 18-day-old Wistar rats with were divided into olive oil, estradiol (0.3 mg/kg), estradiol + tamoxifen (10 mg/kg), SER (5, 15, or 45 mg/kg), ESC (2, 6, or 18 mg/kg), MPH (2.5 or 5 mg/kg), and estradiol + MPH groups. As expected, estradiol increased the weight of uterus, and this effect was counterbalanced by concomitant treatment with tamoxifen. The SER, ESC, and MPH had no effect on the uterus weight. The results suggest that ESC and SER do not share the estrogenicity described for FLX and that MPH does not disrupt estrogenic signaling.
Resumo: Este artigo busca analisar como a Bienal Internacional de Arte de São Paulo gera impacto nos negócios que incidem sobre mercado de arte brasileiro. Uma análise dos dados de exportação de obras de arte publicamente disponibilizados pelo Ministério da Indústria, Comércio Exterior e Serviços durante o período expositivo da Bienal de São Paulo (evento que geralmente ocorre de setembro a dezembro) foi realizada, e, além disso, uma pesquisa com entrevistas com galeristas de arte reconhecidos da cidade gerou novos argumentos acerca das relações entre cultura e negócios.
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