<p class="MsoBodyText2" style="margin-top: 2.5pt; margin-right: 0cm; margin-bottom: 2.5pt; margin-left: 0cm; text-align: justify; text-indent: 35.45pt; mso-pagination: none;"><span style="font-family: 'Times New Roman', serif;">Introdução: Diversas terapêuticas têm sido empregadas no controle do diabetes. Objetivo: O objetivo deste estudo foi avaliar os </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">efeitos da suplementação com L-arginina e do exercício resistido, isolado ou combinado sobre a massa corporal, glicemia e a força </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">muscular de ratos diabéticos. Metodologia: Ratos Wistar foram divididos em 6 grupos: Controle (CON, n = 5), estimulado eletricamente </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">(EE, n = 5), diabético sedentário (DS, n = 5), diabético L-arginina (DL-Arg, n = 5), diabético treinado (DT, n = 5) e diabético treinado </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">+ L-arginina (DT + L-Arg, n = 5). O diabetes foi induzido através da administração de aloxano na dose única de 40 mg/kg, i.v., duas </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">semanas antes do início dos protocolos. Foi avaliada a massa corporal, glicemia e a força muscular no início, a cada duas semanas e </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">no final das 6 semanas dos procedimentos experimentais. Resultados: No início do estudo, o DS apresentou um aumento significativo </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">(p < 0,001) da glicemia quando comparado com o CON. Após as 6 semanas de estudo os animais do grupo DT e DT + L-Arg obtiveram </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">um aumento significativo (p < 0,01 e p < 0,001; respectivamente) nos níveis de força quando comparado com o DS. Os animais DT + </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">L-Arg apresentaram uma redução significativa (p < 0,001) da glicemia plasmática ao longo do tratamento quando comparado com o </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">DS. Conclusão: A suplementação com L-arginina associada ao exercício resistido aumenta a força muscular e promove um equilíbrio </span><span style="font-family: 'Times New Roman', serif; text-indent: 35.45pt;">metabólico em animais diabéticos.</span></p> <br />
The aim of this study was to evaluate the effects of RT on glucose, lipids, urea, creatinine, PCRhs, fructosamine and blood TBARS, and mass indexes heart, liver and muscle in diabetic rats induced by alloxan (40 mg/kg, iv). For all experiments we used male Wistar rats weighing 200–300g. The animals were divided into 3 groups (n=8 for each group), sedentary control (SC), sedentary diabetic (SD) and trained diabetic (TD) rats. The RT was performed in a squat‐training apparatus using 3x10 repetitions, 3 times a week for 8 weeks After measurement of the maximum weight lifted (1RM) the training load was set at 40% of 1RM and adjusted each 15 days. At the end of the RT protocol or time control, the animals were anesthetized with sodium thiopental (45 mg/kg i.p.) and sample blood and tissues were obtained. The RT was able to reduce blood glucose (from 381 ± 42 to 270 ± 17 mg/dL), plasma TBARS (1.4 ± 0.02 to 0.2 ± 0.05 nmol/ml) and liver mass index (0.0467 ± 0.0036 to 0.0391 ± 0.0034), and to increase HDL (from 16.25 ± 2.25 to 36.6 ± 6.7) and plantar muscle mass index (from 0.00295 ± 0.00026 to 0.00377 ± 0.00005) in relation to the SD. These results demonstrate that the low intensity RT is a useful non‐pharmacological intervention to treatment of metabolic complications from diabetes. Research Support: CAPES, Fapitec‐SE.
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