Graphical AbstractOne year r-GH therapy influence on blood gamma-amino-butyric acid, serotonin, dopamine and IGF-1 in 15 growth-hormone deficient children 2 GABA/DA/IGF1 >> 3 Aim: To quantify the effect of 1 year r-GH therapy on blood gamma-amino-butyric acid(GABA), serotonin (5-HT),dopamine(DA) and IGF-1 in 15 growth hormone(GH) deficient children. Research design and methods: This retrospective study included 8 boys (7-14years) and 7 girls (7-14years) with clinically established GH deficit and under GH replacement therapy.In 2016 they were quantified for GABA, DA, 5-HT and IGF-1.After 1 year again of GH therapy they were once more tested for the same parameters using analytical methods. Results: Median plasma parameters in 8 boys pre-vs. post-GH therapy was: GABA: 59.44 vs. 105.83ng/mL; 5-HT: 269.66 vs.196.55ng/mL; DA: 46.66 vs.91.5pg/mL; IGF-1: 367.38 vs. 445.5ng/mL.The same parameters were tested in 7 girls as median pre-vs. post-GH therapy: GABA: 45 vs.96ng/mL; 5-HT: 215 vs.200ng/mL;DA: 40 vs. 60pg/mL; IGF-1: 284 vs.420ng/mL.We established statistical significant differences in boys group pre-and post-treatment in: plasma GABA(P<0.001),serum 5-HT(P<0.01),plasma DA(P<0.02),serum IGF-1(P=0.02). In girls group we calculated statistical significant differences in plasma GABA pre-vs. post-therapy(P<0.001) and in plasma DA pre-vs. post-therapy(P>0.02) Conclusions:In fact replacement GH-therapy improved GABA/5-HT, GABA/DA, GABA/IGF-1,5-HT/IGF-1 correlations in boys group. In girls group we estimated improved correlations between GABA/DA,5-HT/DA, 5-HT/IGF-1.These observations could be translated in general improvement of health state in growth deficient children under GH-therapy Key words:GH deficient children,GH replacement therapy, gamma-amino-butyric acid(GABA),serotonin (5-HT),dopamine (DA) Abstract:
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