OST can be considered cost-effective vs no OST from the UK NHS/PSS perspective, with a cost per QALY well below the UK's willingness-to-pay threshold. There were only small differences between BMT and MMT. The availability of two or more cost-effective options is beneficial to retaining patients in OST programs. From a societal perspective, OST is estimated to save over £14,032 and £17,174 per year for BMT and MMT vs no OST, respectively, due to savings in victim costs. Further work is required to fully quantify the clinical and health economic impacts of different OST formulations and their societal impact over the long-term.
The optoelectronic properties of image sensors, among which are the photosensitivity and resolution, are key to the quality factors for imaging as well as spectrometry in Earth observation and scientific space exploration missions. Microlens arrays (MLAs) further improve state-of-the-art CMOS image sensors (CIS) by redirecting more photons into the photosensitive surface/volume of each pixel. This paper reports the design, deposition, optical characterization, and reliability assessment of such an MLA made from a UV-curable hybrid polymer and replicated on a packaged back-illuminated CIS having a pixel pitch of 15.5 µm. We find that such MLAs are highly stable to temperature variations, exposure to humidity, mechanical shocks and vibrations, as well as irradiation by gamma rays, while improving the parasitic light sensitivity by a factor of 1.8. Such MLAs can be applied on a large variety of image sensors, back-illuminated but mostly front-illuminated, with pixel pitches ranging from a few to several hundreds of micrometers, making them suitable for most specifications of the space industry.
Concerns were raised in our department when four of our patients receiving PUVA treatment developed internal malignancy. We reviewed the medical and phototherapy case notes of patients who received either systemic or bath PUVA therapy in our department between 1986 and 1999. Among the 197 patients for whom we were able to trace the hospital records we identified five patients with internal malignancies. Over the same period (1986-1999) we calculated, using the Kaplan-Meier nonparametric estimator, that 4.6 cases of internal malignancy would have been anticipated in our study population. Therefore PUVA therapy did not appear to be a risk factor for internal malignancy.
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