ObjectiveTo evaluate the impact of enzyme replacement therapy for Gaucher Disease on clinical and laboratory parameters after two, five and ten years of treatment.MethodsData were collected from patient records and analyzed using BioEstat software (version 5.0). Student's t-test, Analysis of Variance (ANOVA), Wilcoxon test and Kruskal–Wallis test were used for statistical analysis. Hepatomegaly and splenomegaly were analyzed using the Kappa test.ResultsThere was a significant increase in hemoglobin levels (p-value <0.01) and platelet counts (p-value = 0.01) within two years of therapy. At the same time, the frequencies of splenomegaly (p-value <0.01) and hepatomegaly (p-value <0.05) reduced. These results were similar at five and ten years of enzyme replacement therapy.ConclusionsThere are substantial and quick (within two years) laboratory and clinical responses to enzyme replacement therapy. These improvements continue as long as enzyme replacement therapy is administered every two weeks, as recommended by the literature.
Objetivo: Estimar a incidência e fatores associados à sífilis congênita (SC) nas Regiões Geográficas Intermediárias (RGIs) no Estado do Pará. Método: Estudo descritivo, quantitativo, analítico, sobre SC no Pará, utilizando dados do Sistema de Informação de Agravos de Notificação de 2007 a 2016. Resultados: Aumento dos casos de SC, sendo Belém e Marabá as RGIs com mais casos. As variáveis que se associaram (p<0,05) com a ocorrência de SC, foram escolaridade materna (RR=1,06; IC95% 1,00-1,25) e cor da pele não branca (RR=0,71; IC95% 0,66-0,77).Altamira teve o maior percentual de mães com idade menor de 20 anos. A realização do pré-natal variou (65,8% a 90,1%). O diagnostico durante o pré-natal teve variação expressiva. Tratamento inadequado das mães e parceiros não tratados prevaleceram nas Regiões Altamira e Marabá, respectivamente. Conclusão: Aumento da incidência em mulheres maiores de 20 anos, em todas RGIs. O tratamento inadequado, ausência de tratamento do parceiro e diagnóstico de sífilis após o parto foram expressivos, justificando a alta incidência da SC.
The presence of lymphocytic alterations in the blood of indigenous people infected with human T-lymphotropic virus 2 (HTLV-2) was investigated in peripheral blood smears from 25 indigenous people of the Xikrin do Bacajá ethnicity (11 men and 14 women) diagnosed with HTLV-2 infection by Western blot and qPCR. Smears were stained using the Leishman method and examined for lymphocyte morphology under an optical microscope. A group of 25 individuals seronegative for HTLV-1/2 infection were used as controls. Among the HTLV-2-infected group, six slides (24%) showed atypical lymphocytes (05 with atypical lymphocytes and 01 with petal-shaped nuclei usually referred to as flower cells). The finding was significantly different from that observed among the noninfected group, in which no lymphocytic alteration was observed (p=0.0223). This unique finding is reported for the first time among indigenous peoples and suggests that HTLV-2 infection may be associated with lymphocytic alterations, reinforcing the need for a larger and more detailed clinical study of people living with HTLV-2, particularly the indigenous populations of the Amazon in which the infection is hyperendemic.
Avaliações hematológicas são frequentemente requisitadas em medicina veterinária. O uso de contadores automáticos recentemente inseridos na rotina veterinária, possibilitou a inserção e avaliação de novos parâmetros sanguíneos. Foram colhidas amostras de sangue de 113 cães de ambos os sexos e diversas raças provenientes de canis da região norte do Brasil. O processamento e as análises hematológicas foram realizados conforme procedimento padrão do laboratório utilizando o contador hematológico automático Cell-Dyn 3700r (ABX Diagnostic, Montpellier, France) incluindo os parâmetros RDW, PCT, PDW e MVP. Não houve diferenças estatísticas entre os sexos e os valores médios encontrados foram RDW (16,44 ± 1,41); PCT (0,36 ± 0,16); PDW (20,16 ± 1,68) e MPV (13,27 ± 3,94) e uma correlação entre PDW X MPV (R2 = 0,810 p < 0,05) e MPV X PCT (R2 = 0,388 p < 0,05). O objetivo do presente estudo foi avaliar os valores dos parâmetros encontrados com outros estudos, comparando-os e revelar os valores de referência dentro de um intervalo de confiança de 95% além de correlacioná-los.
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