A series of the title compounds has been synthesized by two alternative methods in order to study their potential neuroleptical activity and to compare it with the pharmacological data already obtained for compounds of other isomeric or related series.
Während aus den 3‐Aminothiophencarbonsäureestern (Ia) und (IIa) durch normale Diazotierung und Sandmeyer‐ bzw. Schiemann‐Reaktion die 3‐Halogen‐Derivate (Ib), (IIb) und (Ic) erhalten werden, entsteht aus dem 2‐Aminothiophencarbonsäureester (III) das Selbstkupplungsprodukt (IV).
3‐Mercapto‐thiophen‐2‐carbonsäure (I) kondensiert mit den Nitro‐chlorbenzolen (II) zu den Nitrophenylsul?den (III), die über die Aminophenylsulfide (IV) zu den Lactamen (VII) cyclisiert werden.
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