HighlightsHeterotopic ossification (HO) is related with the abnormal bone formation in tissues that normally do not ossify.Heterotopic mesenteric ossification is a rare form of HO, characterized by the formation of an ossificant pseudotumor in the mesenteric base.Pathophysiology of HO has been postulated to be due to osteoblastic metaplasia of multipotent mesenchymal cells in response to stimulus.Prognosis of HO is generally good, so treatment should be conservative, avoiding surgery to prevent further ossification.

HighlightsMalignant melanoma frequently spreads to the gastrointestinal tract (60%).Only 1–4% of melanoma metastases to the gastrointestinal tract are detected before death because most patients are asymptomatic.Gastrointestinal spread of previously treated malignant melanoma should always be considered in patients with digestive symptoms or ferropenic anemia.Small bowel intussusception and gastrointestinal bleeding are unusual presentations of intestinal melanoma metastases.Surgical resection remains the mainstay of treatment, not only providing symptomatic control but also leading to improved survival.

HighlightsPrimary breast lymphoma (PBL) is a rare disease accounting for 0.04–0.5% of all breast malignancies.The clinical and imaging findings in breast lymphoma can mimic those of breast carcinoma.Sometimes, PBL presentation is suggestive of Inflammatory breast cancer.Diagnosis depends on adequate tissue sampling for histology examination and immunophenotyping.The therapeutic management of PBL is controversial and is not clearly established, but many studies support that it is not a surgical disease and can be treated successfully with combined chemotherapy and radiotherapy.Imaging is a useful method to monitor a patient’s response to therapy.

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Marchiafava‑Bignami disease is a rare condition associated with chronic alcohol consumption and/or malnutrition, characterized by demyelination of the corpus callosum, generally attributed to a deficiency in B complex vitamins. We report the case of a 34‑year‑old male with a 10‑year history of alcohol dependence who was admitted to the hospital, after having been found lying on the floor of his house, malnourished and with pressure ulcers on his chest and knees. On clinical observation he was found to be alert but mute. He followed some simple orders. Generalized spastic hypertonia was present. Magnetic resonance imaging showed demyelination of the corpus callosum, suggesting the diagnosis of Marchiafava‑Bignami disease. He was admitted to the Psychiatry Inpatient Unit and evaluated by a multidisciplinary team. He received thiamine, corticosteroids and rehabilitation. After a week, his speech was slurred but comprehensible and he could walk with aid; magnetic resonance imaging findings had improved. After three months in a Convalescence Unit, he was discharged with total autonomy.