The aim of this study was to evaluate the impact of photobiomodulation therapy (PBMT) on histomorphological aspects of submandibular gland (SMG) submitted to salivary gland duct obstruction in hypothyroid rats. Fifty-six male Wistar rats (250 to 300 g) were divided into 4 groups (n = 14): euthyroid (EU), EU + PBMT, hypothyroid (HYPO), and HYPO + PBMT. Duct obstruction of the left submandibular gland (LSMG) was performed in all animals by a ligature procedure. For the induction of hypothyroidism, total thyroidectomy was performed. PBMT groups received irradiation with AlGaInP diode laser (808 nm, 0.04 W, 0.04cm 2 spot size, 60 s, 2.4 J per point, 60 J/cm 2 , 1 W/cm 2 ). Irradiation was performed immediately, 24 h, and 48 h after the obstruction of the salivary gland duct, in one point, extra oral and perpendicular to the gland. Animals were sacrificed after 24 h and 72 h after duct ligature. Our results indicated that salivary duct obstruction and hypothyroidism caused negative modifications on the salivary glands' histomorphology, especially acinar atrophy, after 24 h and 72 h. HYPO + PBMT showed a significant reduction of the inflammatory infiltrate, congested blood vessels, and acinar atrophy in the SMG submandibular salivary gland in 72 h compared to 24 h (p < 0.05). In conclusion, obstruction of the salivary gland excretory duct and hypothyroidism causes severe sialoadenitis with expressive atrophy of the glandular parenchyma. However, PBMT was able to modulate the inflammatory process and delaying acinar atrophy. This study provided insights to better understand the role of the PBMT on the altered salivary gland by duct ligation and associate hypothyroidism.
Introduction: Gorham's disease, correspond to a massive osteolytic disease of the bones, characterized by destruction and resorption of one or more bones, spontaneous and progressive. The etiology of the disease is still unknown. The destroyed bone does not have the ability to regenerate or repair and is replaced by dense fibrous tissue. Bones of the skull and pelvis are the most commonly affected and in maxillofacial bones, the mandible is particularly affected. Case report: This study reports the case of an 11-yearold female, referred to the Oral and Maxillofacial Surgery service showing extensive area of spontaneous bone resorption, in which only the alveolar portion of the mandibular symphysis and the head of the left jaw were present. The history and clinical features observed indicated Gorham's disease. Final considerations: When in progressive stages Gorham's disease is difficult to be diagnosed by histopathological evaluation, due to limited remaining bone quantity, leaving only clinical and complementary exams to make allowances. The treatment is controversial in the literature. Therapy is individualized in accordance with the severity of the patient's condition and the site of involvement.
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