The Industry 4.0 Standard (I4S) employs technologies for automation and data exchange through cloud computing, Big Data (BD), Internet of Things (IoT), forms of wireless Internet, 5G technologies, cryptography, the use of semantic database (DB) design, Augmented Reality (AR) and Content-Based Image Retrieval (CBIR). Its healthcare extension is the so-called Health 4.0. This study informs about Health 4.0 and its potential to extend, virtualize and enable new healthcare-related processes (e.g., home care, finitude medicine, and personalized/remotely triggered pharmaceutical treatments) and transform them into services. In the future, these services will be able to virtualize multiple levels of care, connect devices, and move to Personalized Medicine (PM). The Health 4.0 Cyber-Physical System (HCPS) contains several types of computers, communications, storage, interfaces, biosensors, and bio-actuators. The HCPS paradigm permits observing processes from the real world, as well as monitoring patients before, during, and after surgical procedures using biosensors. Besides, HCPSs contain bio-actuators that accomplish the intended interventions along with other novel strategies to deploy PM. A biosensor detects some critical outer and inner patient conditions and sends these signals to a Decision-Making Unit (DMU). Mobile devices and wearables are present examples of gadgets containing biosensors. Once the DMU receives signals, they can be compared to the patient's medical history and, depending on the protocols, a set of measures to handle a given situation will follow. The part responsible for the implementation of the automated mitigation actions are the bio-actuators, which can vary from a buzzer to the remote-controlled release of some elements in a capsule inside the patient's body. Decentralizing health services is a challenge for the creation of health-related applications. Together, CBIR systems can enable access to information from multimedia and multimodality images, which can aid in patient diagnosis and medical decision-making. Currently, the National Health Service addresses the application of communication tools to patients and medical teams to intensify the transfer of treatments from the hospital to the home, without disruption in outpatient services. HCPS technologies share tools with remote servers, allowing data embedding and BD analysis and permit easy integration of healthcare professionals' expertise with intelligent devices. However, it is undeniable the need for improvements, multidisciplinary discussions, strong laws/protocols, inventories about the impact of novel techniques on patients/caregivers as well as rigorous tests of accuracy until reaching the level of automating any medical care technological initiative.
