The chemical composition of blood varies within rather narrow limit values. Relative constancy is more marked when certain components are concerned and less manifest when others are involved. Thus, mineral components allow narrower quantitative variation limits than organic substances concentration, more precisely than extractive substances, which may vary between wider limits. The variations of the formed elements/plasma ratio, which are common in pathological states, hinder the study of the chemical composition of blood, due to the fact that these oscillations are reflected in the overall chemical composition of blood. In most cases, chemical research needs to be conducted on blood serum and plasma, as they are more constant in their composition.
Tumor anaplasia can be of varying degrees, being especially marked in fast-growing malignant tumors. Blastomatose tissue is characterized by morphological, chemical, physico-chemical and energetic anaplasia. Structural changes of the tissue specific to blastomatose growth often provide the opportunity to differentiate this tissue from a normal or any other growing tissue. Out of various factors that may influence the external environment of tumors, we should mention food, profession, living and working conditions. Tumors and especially malignant tumors are accompanied by changes in the entire body. These are not just a consequence of the blastomatose growth but also play a role in its subsequent development. Experimental tumors are one of the methods of studying the issue of blastomatose growth. The tumor transplantation method is widespread and extensively applied in laboratory practice. It uses standard strains of tumors (rats, mice, etc.). The simplicity of the tumor transplantation method, which consists of the inoculation under the skin of animals of tumor fragments using a trocar or of the injection of a tumor emulsion under aseptic conditions, enables researchers to maintain the purity of the strain for a long time. Various views have been formulated at different times on the origin of tumor growth in accordance with the level of knowledge on this issue.
Sepsiis syndrome is a common and have devastating implications on health care systems worldwide. Biomarkers may have an important role to highlight the presence, absence or severity of sepsis. Retrospective study was conducted on a group of 81 patients with suspected sepsis, presented in the Emergency Department - Emergency County Hospital St. Spiridon Iasi during 01.09.2014-30.10.2014. The obtained statistical data�s were interpreted using SPSS software and the ROC curve was calculated. The study aims was to establish the following: determining the validity of presepsin as a biological marker in sepsis diagnosis and prognosis; sepsis stratification. The mean age of patients was 64.52 years. Determination of presepsin sensitivity in sepsis early diagnosis was calculated by generating the ROC curve. Following AUC values were found: AUC = 0.709, with a standard error of 0.065 for predicting sepsis; AUC = 0.866, with a standard error of 0.080 for severe sepsis; AUC = 0.864, with a standard error of 0.053 in the presence of septic shock. The average values of presepsin, related with severity of infection, it was found to be 544.39 � 141.93 pg./mL in case of localized infection; 605.6 � 59.55 pg./ mL in patients with systemic inflammatory response syndrome; 1283.21 � 195.74 pg./ mL in patients diagnosed with sepsis; 4787.8 � 1980.43pg./mL in patients presenting severe sepsis and 3734.88 � 1732.41pg./mL in patients diagnosed with septic shock. Presepsin level, measured by using quantitative dosage methods, may be helpful in staging patients diagnosed with sepsis and may be used as an indication for initiation of intensive therapy to prevent septic shock. Presepsin level can be used as an early marker of severe prognostic in septic patients.
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