Ana C. Valdivia scite author profile

18 F]FPyKYNE-c(RGDyK) was successfully synthesized by the Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition of alkynes to azides using [ 18 F]FPyKYNE as a prosthetic group in an overall radiochemical yield of 12%-18% (decay-corrected) and >99.5% chemical and radiochemical purities in 125 min including quality control. This simple, fully automated two-step, two-reactor approach consists of a quick and convenient purification of the prosthetic group using silica gel cartridges and its subsequent use for the labeling of the azido-c(RGDyK) peptide via click chemistry.

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Radiosynthesis of N-[11C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs)

Valdivia

Mason

Collins

et al. 2010

Applied Radiation and Isotopes

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N-[11C]-methyl-hydroxyfasudil is a potential biomarker of cardiac hypertrophy

Moreau

DaSilva

Valdivia

et al. 2015

Nuclear Medicine and Biology

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647 Imaging of atherosclerotic vascular lesions in ApoE-/- mice Using [18F]-PyKYNE-c(RGDyK) and PET

Valdivia¹,

Thorn²,

Sleiman³

et al. 2011

Canadian Journal of Cardiology

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Ana C. Valdivia

Synthesis and evaluation of the novel 2-[18F]fluoro-3-propoxy-triazole-pyridine-substituted losartan for imaging AT1 receptors

A fast, simple, and reproducible automated synthesis of [¹⁸F]FPyKYNE‐c(RGDyK) for α_vβ₃ receptor positron emission tomography imaging

Radiosynthesis of N-[11C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs)

N-[11C]-methyl-hydroxyfasudil is a potential biomarker of cardiac hypertrophy

647 Imaging of atherosclerotic vascular lesions in ApoE-/- mice Using [18F]-PyKYNE-c(RGDyK) and PET

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About

Ana C. Valdivia

Synthesis and evaluation of the novel 2-[18F]fluoro-3-propoxy-triazole-pyridine-substituted losartan for imaging AT1 receptors

A fast, simple, and reproducible automated synthesis of [18F]FPyKYNE‐c(RGDyK) for αvβ3 receptor positron emission tomography imaging

Radiosynthesis of N-[11C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs)

N-[11C]-methyl-hydroxyfasudil is a potential biomarker of cardiac hypertrophy

647 Imaging of atherosclerotic vascular lesions in ApoE-/- mice Using [18F]-PyKYNE-c(RGDyK) and PET

Contact Info

Product

Resources

About

A fast, simple, and reproducible automated synthesis of [¹⁸F]FPyKYNE‐c(RGDyK) for α_vβ₃ receptor positron emission tomography imaging