A facile total synthesis of (±)-nimbiol 1 has been achieved. In order to decrease the dioxo byproduct 2a, an improved oxidation system of CrO3/H2O/HOAc/NaOAc was used.
Using Grinard coupling as a key step, a facile synthetic approach to (±)-parahigginone methyl ether 1 and (±)-curcuphenol 2 has been achieved by five steps with 42.3% and 58.6% overall yield, respectively.
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