This study was developed to investigate the expression of TOLL2, TARC and MDC in placenta tissue
of pregnant patients infected with syphilis and their clinical significance. For this aim, placenta samples
were collected from five pregnant patients co-infected with syphilis and five undergoing full-term
delivery before RT-PCR was performed to detect the mRNA expression of TLR2, TARC and MDC
genes. The protein expression of TLR2, TARC and MDC genes was examined by Western Blotting.
Results showed that TLR2, TARC and MDC were expressed in placental syncytiotrophoblast cells of
patients with pregnancy-associated syphilis infection. TLR2 level was found significantly higher in
placenta tissue of patients with pregnancy-associated syphilis infection compared with normal placenta
tissue (P<0.05), so were TARC (P<0.05) and MDC genes (P<0.05). It is concluded that TOLL2, TARC
and MDC levels significantly increased in the placenta tissue of pregnant patients infected with syphilis,
suggesting that the three genes were involved in the molecular pathology of the patients.
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