Fluorescence in situ hybridization (FISH) is a cytogenetic technique used to detect the presence or absence and location of specific gene sequences. It can visualize specific cytogenetic abnormalities (copy number aberrations) such as chromosomal deletion, amplification, and translocation. FISH has been used in prenatal diagnosis and has served both as a diagnostic and as a prognostic marker for various sarcomas. More recently, FISH entered the field of dermatology in aiding the evaluation of ambiguous melanocytic lesions. This article will discuss the concept of FISH, its application, and its advantages and limitations in dermatology, with an emphasis on melanoma.

We report a case of glomuvenous malformation (GVM) in an 11-year-old boy with a history of transposition of the great vessels. The glomulin gene was discovered in 1999, and multiple mutations have been identified with some of the mutations resulting in GVM. The molecular genetics, clinical presentation, histopathology, differential diagnosis, and management of GVM are reviewed. To our knowledge, no case of glomuvenous malformation in the setting of transposition of the great vessels has ever been reported in the literature.

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Drawing on work–family enrichment theory, we explore whether inclusive leadership leads to employees’ work-to-family positive spillover, which further improves their family performance. We also focus on the moderating role of complementary values. A time-lagged study was conducted and the sample included 292 employees from two hotels. The results indicate that inclusive leadership triggers employees’ work-to-family positive spillover, and then their family performance is enhanced. Moreover, employees’ complementary values may strengthen the positive effect of inclusive leadership. We also provide theoretical and practical implications of the results.