The effect of using a mouse, a trackpad and a 3D motion-and-gesture control (3DMGC) on point-and-click task performance, posture and comfort was tested with twelve participants. Performance (movement time, throughput, error); wrist and arm posture; comfort and usability ratings were recorded. Results showed that for performance measures, the mouse performed the best, having the fastest movement time and highest throughput; the trackpad had the least errors. Movement times were significantly slower for the 3DMGC and this had the lowest throughput among the three input devices. Postural analysis using RULA indicate that compared to a mouse and trackpad, posture was worse for ‘clicking’ task with the 3DMCG and this was also rated the least comfortable of the three and the most difficult to use.