These data can be used to update cost analyses of mammography screening that wish to take into account the QOL impact of screening.

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185HMORN 2012 -Selected Abstracts environmental change strategies. To help evaluate the impact of these initiatives we have created a measure of estimated strategy-level impact that we refer to as 'population dose' that provides an overall estimate of the impact of a strategy on food and physical activity behaviors. We provide a definition and examples of measuring population dose and show how the concept was used in an evaluation of the Kaiser Permanente's Healthy Eating, Active Living Community Health Initiative in Northern California (HEAL-CHI). Methods: HEAL-CHI was a community initiative designed to reduce obesity by implementing community-and organizational-level policy and environmental changes in three low-income communities in Northern California. Population dose was defined as the product of reach (number of people exposed to an intervention strategy) and strength (change in behavior for each person reached). Since quantitative effect sizes for policy and environmental change interventions are generally unavailable, we used a three-level rating system to assess the strength of each intervention strategy, combining evaluation results with estimates of intensity. We then examined data from youth surveys to assess whether population-level changes from the youth surveys were greater where high-dose strategies were present. Results: The HEAL-CHI population-level results were inconclusive overall, but showed positive and significant findings for four of the nine youth survey comparisons where "high dose" strategies were implemented, primarily physical activity interventions targeting elementary and middle school-age youth. For example, the percent of children reporting exercising at least 20 minutes per day increased from 61% to 67% in a community implementing a high-dose after-school physical activity program, a statistically significant (p<.05) increase relative to comparison schools. Discussion: The concept of population dose provides a way of comparing the potential community impact of different obesity prevention strategies and combining the estimates from multiple strategies to get an estimate of cumulative impact. In addition, we found that for the HEAL-CHI communities where there were high dose strategies in place there were a number of significant and positive populationlevel behavior changes. Background/Aims: Weight gain is an undesirable side effect of treatment with 2nd/3rd generation antipsychotic drugs which may have genetic determinants. A number of candidate genes have been analyzed but no genome-wide association studies (GWAS) have yet been reported. The purpose of this study was to determine the rate of extreme weight gain (EWG) among adult users of 2nd/3rd generation antipsychotic medications for future GWAS. Methods: A standardized dataset was extracted on antipsychotic medications users at Group Health and Geisinger Health System from 2004-2010 that included demographics, enrollment, vitals, and pharmacy data. Electronic health record search algorithms were used to identify adult subject...

Background/Aims: Programs to translate the Diabetes Prevention Program (DPP) into effective real-life interventions are needed. In the Call-2-Health pilot study we designed and tested a telephone-based intervention modeled on the DPP. Here we present the impact of Call-2-Health on participants' report of support from friends and family for diet changes. Social support may be critical to long-term maintenance of behavioral changes. Methods: Between September 2010 and January 2011, we mailed recruitment letters to 438 overweight English-speaking non-diabetic Group Health members aged 45-74 for whom electronic health records indicated at least one elevated blood glucose or HbA1c. We followed up with phone screening and laboratory tests to confirm eligibility and willingness to participate. Eligible and consenting participants (N=47; 49% men) were randomly assigned 1:1 to usual care (UC) and intervention groups (IG) for the 24-week study. The IG received 12 weekly intervention calls plus 4 maintenance calls over the subsequent 12 weeks. The interventionist delivered a DPP-based curriculum, using motivational interviewing and behavioral techniques to encourage exercise, dietary change, and weight loss. Three UC participants failed to complete the study; IG participants completed 95% of intervention calls. Study questionnaires included the Sallis Social Support scale for eating, completed at baseline and 24 weeks. Results: At baseline, the UC group had mean scores (95%CI) of 10.82 (7.93, 13.70) on the family and 8. 55 (6.43, 10.66) on the friend diet encouragement scales. Mean scores for the IG were comparable, at 10.58 (8.09, 13.08) and 7.17 (6.03, 8.30). At 24 weeks, the measures remained essentially unchanged for UC and increased by 3.71 (1.56, 5.86) (p=0.016) and 3.46 (1.93, 4.99) (p=0.003) for the IG. At 24 weeks the mean weight lost for the IG was 8.6% of baseline weight (5.6, 11.5) as compared to 1.5% (-0.8, 3.9) for UC. Intervention participants' weight loss and their reported increase in dietary support were highly correlated (family r=0.70, friends r=0.64). Discussion: As compared to the usual care group, participants in the Call-2-Health phone intervention reported at 24 weeks a significant increase in supportive behaviors from friends and family regarding dietary change, with increases in support correlating strongly with weight loss success. HMORN 2012 -Selected Abstracts models indicated illicit drug use was associated with a higher likelihood for weekly alcohol use, while being female, a higher daily opioid dose, and greater pain severity was associate with a lower likelihood of weekly alcohol use. Tobacco use, weekly alcohol use, depression symptoms, being male, and middle age was associated with a higher likelihood of illicit drug use. For aberrant drug related behaviors, drug-only use and both alcohol and drug use (compared to no AOD use) were associated with a higher likelihood of receiving opioids from friends or family in the last year, as were postive depressive symptoms and younger age. Both A...