The use of AlloDerm to partially enclose implants effectively prevented formation of a capsule in areas where AlloDerm contacted the implant at 10 weeks. Long-term studies will be required to determine whether this is a durable result that can be reproduced in humans.
Summary
For malaria to be transmitted, the Plasmodium falciparum parasite must invade
an erythrocyte and undergo gametocytogenesis. When mature intraerythrocytic gametocytes
are taken up in a blood meal by a mosquito they emerge as gametes and, once fertilized,
continue to differentiate into infectious sporozoites. One of the major proteins
associated with the surface of the parasite during gamete differentiation is Pfs230,
a 360 kDa member of a family of P. falciparum proteins that contains a repeated
cysteine motif domain. To characterize the role of different regions of Pfs230, the
gene was disrupted by targeted integration and clones isolated that expressed distinct
sections of Pfs230. Independent clones D1.356 a and b express the first 452 amino
acids (aa) of Pfs230 and do not contain a cysteine motif domain, whereas clones D2.850
a and b express the first 950 aa, including the first cysteine motif domain. Although
both sets of clones undergo gametogenesis and produce morphologically normal gametes,
neither truncated Pfs230 is located on the surface of the gamete. In clones D1.356
a and b, the 452 aa Pfs230 is secreted into the parasitophorous vacuole and released
as a soluble protein when the parasite emerges from the erythrocyte as a gamete.
In marked contrast, the 950 aa form of Pfs230 expressed by clones D2.850 a and
b is sequestered in a novel tubular compartment in the erythrocyte cytoplasm. This
sexual‐stage tubular intraerythrocytic compartment (STIC) is not recognized by antibodies
specific for proteins associated with the parasitophorous vacuole membrane (Pfs16
or Exp‐1) or Maurer’s clefts (Pfsbp 1 or mAb LWL1) or intraerythrocytic asexual parasite proteins (PfEMP2 or HRP II).
Current literature suggests that bazedoxifene will likely be safe and effective when used in the treatment of postmenopausal osteoporosis. Completion of Phase III clinical trials will more fully elucidate the safety and efficacy profile of bazedoxifene, as well as more clearly define its place in therapy.
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