New series of 8-nitroquinolone based aromatic heterocyclic acyl hydrazones have been synthesized and characterized through various spectroscopic techniques. They were theoretically examined for molecular docking with various proteins related with...

A progression of new N-(3'-acetyl-8-nitro-2,3-dihydro-1H,3'H-spiro[quinoline-4,2'-[1,3,4]thiadiazol]-5'-yl) acetamide derivatives were synthesized from potent 8-nitro quinoline-thiosemicarbazones. The synthesized compounds were characterized by different spectroscopic studies and single X-ray crystallographic studies. The compounds were...

A progression of novel thiadiazoline spiro quinoline derivatives were synthesized from potent thiadiazoline spiro quinoline derivatives . The synthesized compounds portrayed by different spectroscopic studies and single X-ray crystallographic studies. The compounds were assessed for in vitro anticancer properties towards MCF-7 and HeLa cells. The compounds showed superior inhibition action MCF-7 malignant growth cells. Amongst, the compound 4a showed significant inhibition activity, the cell death mechanism was evaluated by fluorescent staining, and flow cytometry, RT-PCR, and western blot analyses. The in vitro anticancer results revealed that the compound 4a induced apoptosis by inhibition of estrogen receptor alpha (ERα) and G2/M phase cell cycle arrest. The binding affinity of the compounds with ERα and pharmacokinetic properties were confirmed by molecular docking studies.

A one‐pot, multicomponent, convergent microwave synthesis of some new pyranyl‐ and chromenyl‐substituted quinolines has been reported. Twenty compounds were prepared by the reaction of 2‐methoxy‐3‐formyl quinoline (1a‐d), malononitrile (2), and kojic acid (4a‐d)/1,3‐cyclohexadione or dimedone (6a‐h)/α‐ or β‐naphthol (8a‐d, 8e‐h). The structures were confirmed by infrared (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, mass, and single‐crystal X‐ray analyses. On comparison with the use of conventional Lewis acid catalysts and various metal triflates under microwave conditions, the latter contributed to good yields, in specific use of the recyclable Yb(OTf)3 catalyst attributed to high yields of the desired product. The protocol reported herein is solvent free, cost effective, and eco‐friendly.

Background: A novel coronavirus COVID-19 outbreak causing infectious respiratory disorders. COVID-19 disease has no specific treatment. In the traditional medicinal system, different formulations are available for infectious diseases. Objective: This review discusses the significance and utilization of Siddha and Ayurvedic herbal formulations for COVID-19 treatment and provides scientific information regarding the phytochemistry and pharmacological profiles of Indian medicinal plants used in the formulation. Method: The information on medicine and medicinal plants was collected from research papers, review papers, and books available in several electronic databases, including Google Scholar, SpringerLink, and PubMed was explored as information sources. Results: Traditional medicinal plants are potentially used in formulations due to their inevitable therapeutic properties. Phytochemistry and pharmacological properties of medicinal plants used in the formulations served as scientific proof for traditional medicine. Conclusion: The present study explored the great importance of Siddha and Ayurvedic formulations for COVID-19 treatment. Further scientific investigations are a need to explore these formulations as widely acceptable.