Aim: To study the expression of p53, PCNA & CD34 and differentiate the proliferative activity and angiogenesis of Warthin's tumor & different types of adenoid cystic carcinoma. Methods: Hematoxylin and Eosin (H&E) and immunohistochemical staining techniques were used to detect p53, PCNA & CD34 proteins in 20 cases of Warthin's tumor & different types of adenoid cystic carcinoma (solid, tubular & cribriform pattern). Evaluation of immunostaining was done using computer image analyzer system & all data were statistically analyzed. Results: There was a statistically significant difference (P<0.05) in means of expression of p53, PCNA & CD34 between Warthin's tumor & different types of adenoid cystic carcinoma. Conclusion: The expression of p53, PCNA & CD34 have been associated with aggressive tumor progression and thus has been implicated as a predictive and prognostic marker and could provide useful prognostic markers for proliferative activity and good prognostic indicators for recurrence rate of adenoid cystic carcinoma.
The aim of the present study was directed to investigate the effect of Glutathione (GSH) and Selenium (Se) as chemopreventive agents in experimentally induced hamster buccal pouch (HBP) epithelial dysplasia.Material and methods: Twenty five golden Syrian male hamsters were used as experimental animals and divided into five groups (G1, G2, G3, G4 and G5): G1: 5 animals were left untreated. G2: 5 animals, their right buccal pouches were painted with 0.5% 7, 12 dimethylbenz [a] anthracene (DMBA) 3 times a week for 8 weeks. G3: 5 animals were received GSH one week before, as well as during the application of DMPA for 8 weeks. G4: 5 animals were received Se one week before, as well as during the application of DMPA for 8 weeks. G5: 5 animals were received GSH and Se one week before, as well as during the application of DMPA for 8 weeks. After termination of the experiment, all animals were sacrificed, and the buccal mucosa was excised and preparation in order to be examined histologically and immunohistochemically, then statistical analysis based on these examinations was done Results: Regard to expression of Bcl-2, G2 had recorded the highest mean area percentage (44.25%), while G1 had recorded the lowest mean area percentage (6.73%) and there was high significant difference between G1,G2, G3, G4 and G5 where P value was <0.001, while in regard to expression of Bak, G1 had recorded the highest mean area percentage (41.02%), while G2 had recorded the lowest mean area percentage (19.79%) and there was significant difference between G1, G2, G3, G4 and G5 where P value was 0.019. Conclusion:GSH and Se are considered as promising chemotherapeutic agents in prevention of induced HBP epithelial dysplasia and proved important role in apoptosis and proliferation throughout the process of carcinogenesis.
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