Penelitian ini bertujuan untuk 1) menemukan aspek-aspek matematika yang terdapat dalam motif kain tenun kecamatan Kodi Utara dan; 2) menerapkan aspek-aspek matematika yang terdapat dalam motif kain tenun kecamatan Kodi Utara dalam pembelajaran matematika. Penelitian ini dilakukan di Desa waitaru, Kecamatan Kodi Utara. Jenis penelitian ini adalah kualitatif deskriptif. Data diperoleh dari hasil wawancara dari ketiga narasumber yaitu pengrajin kain tenun. Data hasil wawancara berupa hasil analisis motif kain tenun kecamatan Kodi Utara yang kemudian dikaji aspek-aspek matematis berdasarkan 6 aktivitas dasar menurut Bishop (1998). Aktivitas pada pembuatan motif kain tenun pada masyarakat kecamatan Kodi Utara antara lain: 1) designing:merancang pola motif kain tenun, 2) measuring:mengukur jarak menggunakan jengkal setiap motif 3) counting:menghitung banyaknya benang yang diperlukan. Motif kain tenun memiliki aspek-aspek matematika seperti segitiga, persegi, persegi panjang, jajargenjang, trapesium, refleksi dan translasi.
The percentage of interruptions was lower than those in other observational studies, but greater than those in clinical trials. The significance of the causes of interruption was similar and no factor associated with the risk of interruption was found.
POSTERS IU/mL, 45%/55% had severe fibrosis/cirrhosis, 28% had genotype 1a. Up to Week 16, 59% of patients developed grade 1-4 anemia (Hb <11 g/dL or >2.5 g/dL reduction), with 31% severe cases (Hb <9 g/dL or >4.5 g/dL reduction); 206 patients (34%) dose reduced ribavirin, 146 (24%) received EPO, 70 (11%) were transfused, 8 (1%) received iron-based products and 19 (3%) discontinued treatment for anemia. 122 patients (20%) had both a reduction in ribavirin dose and either EPO or a blood transfusion. Results by baseline disease stage are shown below:
Background
Linezolid, an oxazolidinone antibacterial agent, is available for intravenous/oral administration, with activity against Gram-positive bacteria.
Purpose
To evaluate the suitability of linezolid prescribing and use, in terms of therapeutic indications (infections of skin and soft tissues and community-acquired and nosocomial pneumonia), sensitivity of the causative organism(s) and the incidence of thrombocytopenia (platelet count <150000 cells/mcl).
Materials and methods
A retrospective study included all patients treated with linezolid from January to June 2010 in a 300-bed hospital. The authors recorded the following data: demographic data (number of patients; sex), reason for linezolid treatment, number and type of cultures positive for Gram-positive microorganisms. The suitability of linezolid for use was evaluated according to the indications fpr linezolid in a technical tab. The incidence of thrombocytopaenia was determined in patients whose treatment had lasted longer than 2 weeks.
Results
66 patients were included (59.7% male). The average duration of the treatment was 10.7 days (8.8 to 12.6). 37 patients (56%) were treated with linezolid in line with the approved indications in the technical tab. In 7.6% of patients no blood culture was performed prior to initiation of the treatment. In order to monitor the safety of the treatment, the blood picture was tested on as many patients as possible. Four of these patients developed thrombocytopenia (30.8%).
Conclusions
A high percentage of indications for which linezolid is prescribed in our hospital did not apply to those approved in the SmPC. Only in 8% of cases was a blood culture not performed prior to initiation of therapy, as recommended in the SmPC. Haematological toxicity in patients being treated with linezolid for more than 14 days was higher (30.8%) than indicated in the SmPC.
The administration of the HLA-B*5701 gene test may be of benefit in clinical practice, because it prevents diagnostic errors of the hypersensitivity reaction and enables more accurate interpretation of the symptoms.
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