I2-TBHP-catalyzed oxidative cross coupling of N-sulfonyl hydrazones with isocyanides has been realized for the synthesis of 5-aminopyrazoles through formal [4 + 1] annulation via in situ azoalkene formation. Notable features are the metal/alkyne-free strategy, C-C and C-N bond formation, atom economy, catalytic I2, broad functional group tolerance, good reaction yields, shorter time, and also applicability to one-pot methodology.
A novel strategy has been identified for the regioselective synthesis of 3,4-disubstituted quinolines and 2,3,5-trisubstituted pyrroles from simple alkenes via anti-Markovnikov selectivity under palladium catalysis. The salient features are synthesis of two different heterocycles, readily available starting materials, broad substrate scope, moderate to good yields and use of molecular oxygen as a terminal oxidant.
An efficient, mild and practical approach for the synthesis of amides from nitriles and peroxides is reported in the presence of boront rifluoride ethereate. In this protocol, we utilized peroxides as C 1 synthons for the amidation reaction. Also,w es uccessfullyp repared boron-containing b-ketoamides in ao ne-pot assembly from b-ketonitriles.Avariety of functional groups were tolerated in moderate to good yields.R adical inhibition studies showedt hat the reaction proceeded via anon-radicalp athway.
Herein
we have disclosed a Zn(OTf)2 catalyzed synthesis
of C2-alkyl substituted indole derivatives via unprecedented carbonyl
group migration from o-amido alkynols. The key features
of this protocol involve N,O-carbonyl group migration, broad substrate
scope with varied functionality tolerance, moderate to good yields,
and 100% atom economy. The crossover experiments proved that the migration
is happening via an intramolecular pathway.
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