Background: Obesity is a dilemma nowadays for increasing percentage of people worldwide. Obesity induced oxidative stress due to increased tissue lipid levels, threatened redox state of cell and increased free radical formation leads to tissue oxidative stress. Fatty liver disease is a very common disorder related with obesity resulting in storage of fat goblets in the liver tissues leading to altered redox state called oxidative stress. Aim: To relate the outcome of Stevia and Rebaudioside A on Oxidative stress (MDA, SOD) in Obese Sprague Dawley Rats. Place and duration of study: Physiology Department of Islamabad Medical and Dental College, Islamabad, in collaboration with National Institute of Health (NIH) from 1st January 2020 to 30th June 2022. Methodology: One hundred and twenty healthy male Sprague Dawley rats were included. The animals were divided randomly into four groups of 30 rats each by simple randomization technique. Group 1 was given normal diet while the other three groups were given high fat diet. Stevia leaves and Rebaudioside A (rebiana) were further added for six weeks in the diet of Group 3 and 4 respectively. All animals were sacrificed at the end of study. Results: High fat diet induced oxidative stress in obese group was restored to approximate normal values of SOD (0.001) and MDA (0.001) by treatment with stevia and rebiana both (0.899). Conclusion: Stevia and Rebiana both cause improvement of oxidative stress unrewarding of expensive extraction procedures. Keywords: Stevia rebaudiana, Rebaudioside A, Sprague Dawley rats, Oxidative stress, NAFLD
Objective: To determine the perception of pregnant patients regarding the COVID pandemic, preventive measures taken by the patients during the pandemic, and the impact of COVID on their Natal, Intrapartum, and Postpartum Care.Materials and Methods: This study included 850 patients presenting in the Obstetrics and Gynaecology department for antenatal care, inpatient care (delivery and caesarean section), and postpartum complications. Percentages were calculated for descriptive variables like demographic factors, source of information, and opinion of patients about COVID-19, preventive measures are taken by the patients, their Antenatal, Natal, and Postnatal fears. An independent t-test was applied and a p-value of ˂0.05 was taken as statistically significant.Results: We enrolled 850 patients in this study with a mean age of +28 years,mean gravidity of +3, 50% were matriculated and 75% of our patients belonged to middle-class families.. Among our patients, 96% were in fear of getting infected along with their fetus, if they visited the hospital for antenatal care, which is why a majority of them did not visit the hospital for antenatal care and a statistically significant percentage (80%) of them missed antenatal care for 5 months. While the same number of patients (96%, p-value ˂0.05) shared their fear regarding contracting the infection from the hospital during delivery and postnatal care in the hospital, and the same percentage were of the opinion that the baby would get infected during and after delivery in a hospital.Conclusion: Antenatal care is a basic right of every pregnant female. During emergencies like pandemics ways and means should be devised, not only to provide care but, also, to address the fears of pregnant females to prevent complications during this important phase of life.
Introduction: Hepatic dysfunction is a highly varied condition that can show up as minor damage with elevated levels of transaminases, or appear as extensive damage and failure of liver cells. Thus, in order to reduce associated morbidity and mortality, this ailment should be diagnosed at the earliest possible so that appropriate therapy can be instituted. Our study was carried out to observe hepatic damage in patients with dengue fever (DF) by measuring alanine transaminase levels. Materials and Methods: A cross-sectional study of three months duration was carried out in the Department of Medicine, Dr. Akbar Niazi Teaching Hospital affiliated with Islamabad Medical & Dental College, Pakistan. The sampling technique was Non-Random consecutive sampling and 118 patients were included in our study. Serum Alanine Transaminase (ALT) (normal = 7-56 IU/L), serum Aspartate Transaminase (AST) (normal = 10-40 IU/L) were determined and ultra-sound abdomen was performed. Statistical analysis was done using SPSS Version 24. The Chi-square test was used to observe the relationship between categorical variables. Phi, Cramer’s V, Pearson’s, and Spearman’s Correlation tests were used to study the association of age and gender with ALT levels. Results: There were 72% males (n=85) and 28% females (n=33). Patients were grouped according to age and mean ALT (95+86 IU/L) and AST (134.7+ 98 IU/L) levels were calculated in the different age groups. These levels were found to be significantly raised (P=0.00) in the age groups of 9-18 years and 19-25 years as compared to the other age groups. Moreover, males had high ALT levels as compared to females, however, a significant difference was not observed. There was also no association seen of gender with raised ALT levels (P=0.564), Phi & Cramer’s V=0.56, and Spearman’s correlation coefficient=0.320.Conclusions: ALT and AST levels were elevated above the normal in our sample indicating hepatic involvement.
Objective: To ascertain the impact of levocarnitine on adiponectin and serum lipid levels in a T2DM mouse model. Design of the study: Randomized controlled trial Place and Duration of Study: Department of Physiology, Army Medical College, Rawalpindi from 1stSeptember 2015 to 31stAugust 2017. Methodology: Forty healthy BALB/c mice, which were allocated to two groups. The mice were initially given a high-fat diet for a fortnight and then induction of T2DM was performed by injecting them with streptozotocin intraperitoneally. Group I was taken as diabetic control, and group II was given levocarnitine. After six additional days, blood samples were analyzed for insulin, adiponectin and lipids. Results: Adiponectin blood level was significantly increased and an improvement in lipid profile was observed in the levocarnitine group, when compared with control group. In the diabetic control group, a positive significant correlation was observed between (HDL-C) high density lipoprotein levels and adiponectin levels. Additionally, this group also showed total cholesterol and low-density lipoproteins (LDL-C) are negatively proportionate to the adiponectin. Conclusions: The addition of levocarnitine increases serum adiponectin levels and improves dyslipidaemia in a type of diabetic rats. Keywords: Adiponectin, Levocarnitine, Lipids
Aim: To determine the ramifications of soft drinks on Body Mass Index and effects on various renal parameters. Study design: Cross-sectional study Place and duration of study: HBS Medical and Dental College from 1st January 2020 to 31st December 2021. Methodology: One hundred and ten students from first year to final year MBBS were recruited from Medical Colleges of Islamabad. We assessed caffeinated sugar beverage consumption (Sprite, Mountain Dew, Coke, Pepsi & 7-Up). Inclusion criteria consisted of users (n=48) who took caffeinated soft drinks at least 5-7 glasses/week. Those who took less than this drink was labelled non-users (n=62). Questionnaire we used was self-administered about sociodemographic data, height, weight, soft drinks consumption frequency, and a record of urine R/E Combi 10 strip test. Results: There were 41(37.3%) males and 69(62.7%) females. The percentage of underweight, normal, overweight and obese students was 31.8%, 36.4%, 22.7% and 9.1% respectively. Out of total females (62.7%), the group overweight (30.4%) and obese (10.1%) was highly significant. (p=0.008). The user students n=48(43.6%) took caffeinated drinks more than 5-7 glasses/week and were found to be significantly obese p=0.17 as compared to non-users n=62(56.4%).Soft drink consumption was significantly associated with proteins appearance in urine (p=0.00) and leucocytes (p=0.17) and the mean PH of urine of soda users was highly significantly acidic (p=0.00) by using combi-10 test strips. Conclusion: Very high sugar contents and other ingredients in soft drinks can be associated with obesity, metabolic and kidney disturbances in young students which in chronic cases exacerbate the condition. Keywords: Obesity, Urine disorder, Caffeinated drinks
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