A significant number of stroke and TIA patients who underwent PSG have PLMs and moderate-severe OSA. Stroke and TIA patients with atrial fibrillation are more likely to have moderate-severe OSA and may benefit from PSG evaluation.
Introduction: Periodic limb movements (PLMs) and obstructive sleep apnea (OSA) have been associated with an increased risk of cardiovascular disease. There are limited data on the frequency of PLMs and OSA among a diverse cohort of stroke patients and their association with resistant hypertension and atrial fibrillation (AF). Hypothesis: Stroke and TIA patients with PLMs or moderate-severe OSA are more likely to have resistant hypertension and AF than patients without these findings on diagnostic polysomnography (PSG). Methods: Consecutive stroke and TIA patients referred by a vascular neurologist for PSG from October 1, 2012 to September 30, 2015 were included in this analysis. Baseline clinical characteristics and PSG results were collected retrospectively. The frequency of PLMs (mild ≥5/hour, severe ≥15/hour), arousals due to PLMs (≥5/hour), and moderate-severe OSA (Apnea-Hypopnea Index≥15) was evaluated by PSG to determine their association with AF and resistant hypertension, defined as patients whose blood pressure was not at goal with 3 antihypertensive agents of different classes or controlled with 4 or more medications. Results: Of 103 patients (mean age 60±15 years, 50% female, 61% non-white, 76% ischemic stroke, 23% resistant hypertension) who underwent PSG (median time from cerebrovascular event to PSG 5 months), 48% had mild PLMs, 28% had severe PLMs, 14% had frequent PLM arousals and 22% had moderate-severe OSA. In multivariable analyses, non-white race was associated with lower likelihood of mild (OR 0.32, 95% CI 0.13 to 0.80) and severe PLMs (OR 0.29, 95% 0.10 to 0.79) and female sex was associated with lower likelihood of frequent PLM arousals (OR 0.38, 95% CI 0.14 to 1.00). Factors associated with moderate-severe OSA included older age (OR 1.06, 95% CI 1.016 to 1.106) and the presence of AF (OR 4.26, 95% CI 1.17 to 15.44). There was no significant association between PLMs, PLM arousals or moderate-severe OSA with resistant hypertension. Conclusions: A significant number of stroke and TIA patients have PLMs and moderate-severe OSA. Stroke and TIA patients with AF are more likely to have moderate-severe OSA and should be referred for PSG. The presence of resistant hypertension was not associated with PLMs or moderate-severe OSA in our study.
Introduction: The frequency of obstructive sleep apnea (OSA) among stroke and TIA patients varies from 14% to 72% depending on apnea-hypopnea index (AHI) cut-off points and the study population. Various screening tools have been validated in unselected patients referred for diagnostic polysomnography (DP) but a screening tool that identifies stroke/TIA patients at highest risk of moderate-severe OSA is lacking. Hypothesis: A simple screening tool that considers medical comorbidities and sleep-related symptoms can identify stroke/TIA patients who are most likely to have moderate-severe OSA. Methods: Consecutive stroke and TIA patients referred by vascular neurology for DP from September 2012 to February 2015 were included in a retrospective analysis. Baseline clinical characteristics, DP results and outcomes were collected retrospectively. Moderate-severe OSA was defined as AHI≥15. Results: Of 65 patients (mean age 61±14 years, 48% female, 51% African-American) included in this analysis, 19 (29.2%) were diagnosed with moderate-severe OSA. In multivariable analysis using backward elimination (entry and exit thresholds 0.15), predictors of moderate-severe OSA included history of Coronary artery disease, Hyperlipidemia, older Age, history of Atrial fibrillation, former or current Tobacco use and self- or family-reported Snoring or daytime Sleepiness (CHA2TS2). Variables excluded were sex, race, hypertension, diabetes, depression, chronic obstructive pulmonary disease, patent foramen ovale, body mass index, stroke subtype and wakeup onset . The CHA2TS2 model had excellent predictive power for moderate-severe OSA (AUC= 0.91). CHA2TS2 ≥5 had 100% sensitivity and 54% specificity for detecting moderate-severe OSA. Conclusions: We developed a simple screening tool that can identify stroke and TIA patients who have high likelihood of having moderate or severe OSA identified on their DP. Prospective validation of CHA2TS2 score is currently underway.
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