Background: The major imaging method for early diagnosis of breast cancer is screening mammography. One and half to four years before a malignancy becomes clinically apparent, mammography may identify it. Faster scanning times in the mammography suite are possible with contrast-enhanced spectral mammography. Clinical effectiveness of contrastenhanced spectral mammography for detecting asymmetry in mammograms was assessed in this study. Objective: Assessment of possible role of contrast-enhanced spectral mammography for diagnosing breast asymmetry. Methods: Breast asymmetry, and contrast-enhanced spectral mammography were all looked for in PubMed, Google scholar, and Science direct. References from relevant literature were also evaluated by the authors, but only the most recent or complete study from March 2006 to April 2021 was included. Due to the lack of sources for translation, documents in languages other than English were ruled out. Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted. Conclusion: Especially for women with dense breasts, contrast-enhanced spectral mammography has the potential to be effective in identifying lesions that would otherwise go undetected due to breast asymmetry. This would improve the rate at which breast cancer is detected in its earliest stages.
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