Equisetum arvense L. (common horsetail) has medicinal characteristics that have been known since ancient times and are used to cure a variety of ailments. The effect of E. arvense L. on rats with induced osteoporosis was investigated. Forty female rats were randomized in 5 equal groups (n=8). The first group was working as tricks (SHAM) (negative control), while the other 4 groups were operating with ovariectomized (OVX) and fed on basal diet deficient in calcium and were given orally prednisone acetate (4.5 ml/kg body weight/day twice a week) for two weeks as source of glucocorticoid, to induce osteoporotic models. Three weeks after ovarian removal, Group 2 kept as positive control (OVX) and the other three groups were fed on basal diet supplemented with 5, 10 and 15% of dried E. arvense L, respectively for 8 weeks. The results showed that rats fed on dried E. arvense L. at all tested levels had significant increase (P<0.05) in serum of calcium (Ca), phosphorus (P), bone alkaline phosphates (b-ALP), free thyroxin (T4), calcitonin (CT) and superoxide dismutase (SOD) while significant reduction (P<0.05) in parathyroid hormone (PTH) and malondialdehyde (MDA)was detected. In addition, significant increase (P<0.05) in bone mineral density (BMD), bone mineral content (BMC), Ca and P contents in Femur ash were recorded in cured groups as compared to the positive control group. Our findings exhibit that E. arvense L. had a potent anti-osteoporotic effect in ovariectomized rats due to enhanced bone building, delayed bone loss and normalization of hormones levels that regulate calcium metabolism. Thus E. arvense L. might represent as a natural therapy for the avoidance of osteoporosis in women at postmenopausal period.
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