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Coronavirus disease-2019 (COVID-19) is a respiratory tract infection, accompanied with severe or fatal
pneumonia like symptoms and sometime death. It has posed to be an ongoing global health emergency caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to a sudden outbreak and a large number of infections and
deaths, it became a major concern all over the world. The options available as effective therapeutic, should be urgently
exercised to handle this pandemic disease. So far, no specific and accurate anti-SARS-CoV-2 treatment is recommended
because of the absence of sufficient clinical evidence. In such cases, the clinical use of available drugs is always
considered to be on top priority. A broad-spectrum antiviral agent, Remdesivir is found effective in many cases and
recommended by many clinicians in many countries. This drug acts as a potential inhibitor of viral RNA-dependent RNA
polymerase protein, and thus likely to be efficacious in SARS-CoV-2 infection. Tocilizumab is currently recommended by
many hospitals as an alternative treatment for critically ill COVID-19 patients. The tocilizumab has been administered to
control cytokine storms that occurred due to the release of proinflammatory cytokine including interleukin 6. Chloroquine
and hydroxychloroquine were also used in hospitals, to handle severe COVID-19 patients. Currently, plasma therapy has
been exercised as a therapeutic alternative, especially to handle severe COVID-19 patients. In addition, herbal medicines
are expected to play significant role in the control and prevention of COVID-19. All these therapeutic options have their
advantages and limitations. This review highlights the therapeutic potential of these available drugs, along with their
mechanism of action and shortcomings. We have provided detailed information on available therapeutic options, which
have proved to be effectual in improving clinical symptoms of severe COVID-19 patients.
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