Amlodipine is a calcium channel blockers and belongs to class Dihydropyridines and used to reduce systemic vascular resistance and arterial pressure. Nevertheless, they remain the major case of cardiovascular drug overdose that often leads to lethal outcome. We report the case of intoxication with Amlodipine. This caused severe hypotension, in young health care worker. Patient was initially treated in our ICU with leg and elevation, fluids, calcium gluconate, noradrenaline, glucagon.

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Objective:Triple negative breast cancer (TNBC), despite being the uncommon subtype, contributes a major portion to mortality and associated with poor prognosis. The purpose of this study was to evaluate the cytological criteria for the diagnosis of TNBC through fine-needle aspiration cytology (FNAC).Material and Method:Clinical, cytological, histological, and immunohistochemical (IHC) data of 256 patients were evaluated, and patient were classified as TNBC and non-TNBC phenotype by IHC. All cytological specimens were reviewed for 12 criteria: cellularity, tubule/gland formation, syncytial clusters, large bare nuclei, nuclear atypia, chromatin pattern, cell borders, nucleolus, cytoplasm, lymphocytic infiltrate, calcification, and necrosis. The Fischer's exact test was used to show test association.Result:Out of 256 patients, 82 patients were TNBC, and 174 patients were non-TNBC. TNBC phenotype showed statistically significant association to cellularity, tubule/gland formation, syncytial cluster formation, bare nuclei, nuclear atypia, cell borders, lymphocyte infiltration, and necrosis.Conclusion:FNAC can be helpful in making diagnosis of TNBC and along with ER, PR, HER2 characterization, helpful in planning treatment strategy, saving time, manpower, and resources in the patient management.

After initial intervention for management of coarctation of aorta, recoarctation rates remain variable with different surgical approaches for repair of coarctation of aorta, ranging between 10-41 percent. Various techniques remain prevalent and preferable in different situations and patients of different ages. The most common reintervention is done for restenosis after endovascular balloon dilatation and open surgical repairs. Aneurysmal degeneration is another cause of reintervention, seen after surgical repair and endovascular repair. Endovascular procedures, balloon dilation, stent grafting, and open surgical repairs may be applicable for reintervention. There are specific challenges and risks related to reintervention using either endovascular procedures or open surgical repairs as strategies for restenosis and aneurysms after the previous coarctation of aorta repair.

Patients with D-TGA with atrial level mixing of systemic and pulmonary blood, the morphological left ventricle supports the low pressure pulmonary circulation and regresses in mass and volume as time passes. The LV once regressed is unable to support the high pressure systemic circulation after ASO. These patients are candidates for early ASO, preferably within 3 weeks of life. As age progresses, the scope of these surgical procedures skews and an atrial switch remains the only option to improve quality of life. In Atrial switch, the pulmonary and systemic circulation is returned into an "in series" circulation and cyanosis is obliterated.