Patients with OA incur greater healthcare resource utilization and costs than patients without OA, with substantial variation by joint location.

Pancrelipase improved fat and protein absorption in patients with EPI due to chronic pancreatitis or pancreatectomy, with or without DM, and matched the safety profile previously reported.

No abstract

Bodhani (2019) Development and content validity of new patient-reported outcome questionnaires to assess the signs and symptoms and impact of atopic dermatitis: the Atopic Dermatitis Symptom Scale (ADerm-SS) and the Atopic Dermatitis Impact Scale (ADerm-IS),

We investigated the relationship between self-reported adherence to pancreatic enzyme replacement therapy (PERT), nutritional status, and all-cause hospitalization in cystic fibrosis (CF) patients with a record of PERT use. Association of self-reported annual PERT use rate (adherence) with annual hospital admission rate (HAR) and annual total hospital nights (THNs) were analyzed for 5301 children (2000–2012) and 13,989 adults (2000–2013) from the CF Foundation Patient Registry. Multivariate linear regression was used to determine the association of HAR and THN with mean annual PERT use rate, cumulative PERT use rate, mean body mass index (BMI) (adult) or BMI percentile (pediatric), age, and sex. The median annual PERT use rate was 87% in children and 80% in adults. Statistically, higher annual PERT use, longer cumulative PERT, and higher BMI percentile (children) or BMI (adults) were significantly ( p < 0.0001) associated with lower annual HAR and fewer annual THN in children and adults. Female sex was associated with higher annual HAR and more annual THN in children and adults ( p < 0.05). Results indicate self-reported adherence to PERT, increased BMI, and male sex were associated with fewer hospital admissions and annual hospital nights in CF patients.

The HIS-Q-SF is a comprehensive measurement of hypogonadism symptom severity in men. Content coverage and content validity were confirmed. The instrument will be evaluated further to establish the psychometric characteristics and to assess the utility of the measurement in clinical treatment settings.

The study was designed to investigate the influence of type 2 diabetes mellitus (T2DM) on articular syndrome and parameters of cytokines in patients with osteoarthritis (OA). Methods: The study involved 49 patients (10 males), aged 56.37±1.17 with OA and T2DM in Regional Hospital of Kharkov. All patients were divided into 2 groups: group 1 (n¼21)-with OA, group 2 (n¼28)-with combined course of OA and T2DM (BMI<30 kg/m2). Baseline characteristics of patients included history of OA (1st group-8.52±0.53 years; 2nd group-7.39±0.52 years), T2DM (9.85±0.97 years). The survey plan included anthropometric data, global knee pain [visual analog scale (VAS)], the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), indices of carbohydrate exchange (insulin, glucose, HbA1C, HOMA-IR). The level of HbA1C was <7.5% in all patients. The level of C-reactive protein (CRP) was determined by using of a latex test. The level of TNF-a and IL-1b was determined by ELISA. The X-ray examination of knees was performed for all patients. Results: A statistically significant relations between the degree of diagnosis complexity and radiological changes by Kellgren were found (M-L X^2¼15.58 p¼0.0036<0.05). The indices of WOMAC Pain score and WOMAC stiffness were similar in both groups, but the indices of WOMAC physical function subscore were significantly higher in the 2nd group (M-W U¼88, Z¼À4.167, p¼0.00003). The levels of TNF-a, IL-1b and CRP were higher in group with OA and T2DM, however the difference was not significant. We found significant correlation between TNF-a and IL-1b in both groups (1st-r¼0.66; р<0.05; 2nd-r¼0.70; р<0.05). The significant correlation between TNF-б and CRP was determined in group of patients with OA (r¼0.46; р<0.05) as well as in the group with combined course of OA and T2DM (r¼0.82; р<0.05). Also the correlation between IL-1b and CRP was determined in 1st group(r¼0.48; р<0.05) and in the 2nd group as well (r¼0.52; р<0.05). The level of indices of WOMAC Pain score correlated with TNF-a (r¼0.63; р<0.05), IL-1b (r¼0.45; р<0.05) and CRP (r¼0.66; р<0.05) among the patients of the 1st group. We determined significant correlation between WOMAC Pain score and TNF-a (r¼0.44; р<0.05), IL-1b (r¼0.47; р<0.05); between WOMAC stiffness and TNF-a (r¼0.39; р<0.05), also between WOMAC physical function score and CRP (r¼0.29; р<0.05) in the 2nd group with comorbid pathology. Conclusions: The study demonstrates that T2DM was associated with more pronounced radiographic changes and more severe changes of physical function in patients with comorbid OA. Significant correlation between TNF-a, IL-1b and CRP in patients with combined course of OA and T2DM suggests that T2DM can be an important factor that contributes to derangements of immune and metabolic processes and progression of OA.

native. Only direct medical costs were considered. Costs and outcomes were discounted at 5% yearly. The outcomes considered were life years (LY) and quality adjusted life years (QALY). RESULTS: The incremental cost-effectiveness analysis demonstrated that AA is the most economically attractive medication. When the incremental cost-effectiveness ratio (ICER) for LY and QALY gained was evaluated, AA was dominant with regards to C, being more effective (LY: 1.3559 vs 1.2895; QALY: 0.7977 vs 0.7329) with lower costs (R$79,974 vs R$90,025). CONCLUSIONS: AA is the best therapeutic option, with the best cost-effectiveness ratio, versus C for the treatment of patients diagnosed with advanced mCRPC under Brazilian private perspective.