Organophosphorus-based nerve agents, such as paraoxon, parathion, and malathion, inhibit acetylcholinesterase, which results in paralysis, respiratory failure, and death. Bacteria are known to use the enzyme phosphotriesterase (PTE) to break down these compounds. In this work, we designed vacancy-engineered nanoceria (VE CeO2 NPs) as PTE mimetic hotspots for the rapid degradation of nerve agents. We observed that the hydrolytic effect of the nanomaterial is due to the synergistic activity between both Ce(3+) and Ce(4+) ions located in the active site-like hotspots. Furthermore, the catalysis by nanoceria overcomes the product inhibition generally observed for PTE and small molecule-based PTE mimetics.
Organophosphorus-based nerve agents,s uch as paraoxon, parathion, and malathion, inhibit acetylcholinesterase,w hich results in paralysis,r espiratory failure,a nd death. Bacteria are knownt ou se the enzyme phosphotriesterase (PTE) to break down these compounds.I nt his work, we designed vacancy-engineered nanoceria (VE CeO 2 NPs) as PTE mimetic hotspots for the rapid degradation of nerve agents.W eo bserved that the hydrolytic effect of the nanomaterial is due to the synergistic activity between both Ce 3+ and Ce 4+ ions located in the active site-like hotspots.F urthermore, the catalysis by nanoceria overcomes the product inhibition generally observed for PTE and small molecule-based PTE mimetics.
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