Bone marrow-derived MSCs have the capacity to differentiate into IPCs capable of controlling the blood glucose level in rats with STZ-induced diabetes. Furthermore, treatment with MSCs and IPCs can improve aberrant biochemical parameters in an STZ-induced diabetes model.
Diabetes is a metabolic disorder that occurs due to a deficiency in insulin secretion, action or both of them. Apigenin is a potent antioxidant, found mainly in celery. Therefore, this study aimed to display the biological activity of apigenin and it is a role in lowering blood glucose levels. Apigenin has been extracted from celery and administrated daily to streptozotocin-diabetic rats for six weeks. Apigenin significantly minimizes blood glucose level, the activities of á-amylase, lipid profile and malondialdehyde in serum. On the other hand, liver glycogen has been elevated in diabetic rats that treated with apigenin. The histopathological and immunohistochemical results confirmed that apigenin can decrease degenerative changes in the pancreatic â-cells. So, this study, depicts that apigenin considers a hypoglycemic agent with the potency to normalize odd in the biochemical parameter of diabetes and keep the normal architecture of the islet cells of the pancreas.
Sodium nitrite is used as a preservative in food products to stabilize color and reduce rancidity. Its absorption into the body causes many diseases. Ellagic acid is a natural polyphenol that contains powerful antioxidants, but it is taken as a poorly absorbed food. Therefore, chitosan-coated nanoparticles (EANP@CS) were loaded to enhance their bioactivity and bioavailability after oral administration. EANP@CS was administrated in rats given water containing sodium nitrite to reduce toxins. Ellagic acid was extracted from pomegranate and manufactured EANP@CS. EANP@CS was identified by FT-IR, UV, X-ray diffraction and TEM. Average EANP@CS size ranges from 20-62 nm. Rats were divided into five groups: normal, treated using EANP@CS; rats were receiving nitrite for 8 weeks, and the last two groups were treated with EANP@CS. Serum and liver NO, MDA, and DNA fragmentation were reduced. Liver thiol and GSH levels, and Gpx, catalase and GST activities increased in rats treated with EANP@CS rats compared to rats drinking nitrites. Liver NOS activity was reduced 7 and 4.9 times in rats treated with EANP@CS during or after discontinuation of nitrite administration, respectively. Liver arginase activity was raised in rats that drink nitrite or were treated using EANP@CS. Inflammatory infiltrations of the liver, kidney, and spleen were observed in the tissues of rats that received nitrites and improved when the rats were given EANP@CS. EANP@CS improved oral bioavailability and reduce the risk of sodium nitrite in rats. EANP@CS can be used as a therapeutic goal to detoxify any unwanted toxic substance in food.
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