INTRODUCTION:Vitamin D3 insufficiency has become a severe health problem that affects more than one billion people worldwide. Maternal vitamin D3 deficiency can induce dentin defects during tooth development. OBJECTIVES: To evaluate the biological effect of maternal vitamin D3 deficiency on dentinogenesis of the rat offspring. MATERIALS AND METHODS: Twelve female Albino rats were used. Rats were divided randomly into two equal groups. In the control group, rats were fed normal balanced diet and exposed to the normal light/dark cycle. In the study group, rats were housed in incandescent light devoid of ultraviolet B-light and fed a diet free of vitamin D3.Vitamin D3 level in the serum was measured every two weeks till reached vitamin D3 deficiency. Female rats were mated to be pregnant. At the fourth day after labor, two pups were taken from the litter of each mother. The dentinogenesis of the developing mandibular first molars was examined by the light and transmission electron microscope and evaluated by histomorphometric analysis. RESULTS: Vitamin D3 deficiency harmfully affected odontoblast differentiation, dentin formation and mineralization. CONCLUSION: Maternal vitamin D3 deficiency during tooth development has an adverse effect on odontoblast differentiation, dentin formation and mineralization.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.