Emergence of direct antiviral agents (DAAs), and campaign done by the National Committee for Control of Viral Hepatitis (NCCVH), reduced chronic hepatitis C (CHC) prevalence in Egypt. This study evaluated the efficacy and safety of used DAAs in affiliated centers from October 2017 to December 2019. Patients were either started treatment or during follow-up for 1 year after therapy (EOT). They were divided according to treatment into GI: SOF/DAC for 12 weeks, GII: SOF/DAC/ RBV for 12 weeks, GIII: SOF/SIM for 12 weeks, GIV: SOF/RBV for 24 weeks and GV: SOF/ DAC/RBV for 24 weeks. DAAs were effective in all groups, and adverse effects occurred in 54 patients (38.6%).The commonest complications were ascites (n=18) followed by jaundice (n=17) and HCC (n=14). Patients (97.1%) in GIV complained of adverse effects compared to others with a significant difference (p<0.001). Hematemesis occurred in one patient in GIV. There was also a significantly higher proportion of ascites (38.2%) in GIV compared to others (P < 0.01), without significant differences between groups regarding HCC and renal impairment (RI) (P= 0.316 & 0.758 respectively). Five treatment experienced patients suffered from side effects. Renal impairment was (12.5%) among interferon (IFN) experienced and SOF/DAC experienced patients and who were treated among GIV and GV, hepatic encephalopathy was (12.5%) in IFN experienced and SOF/RBV experienced patients among GIV or GV, but ascites (6.3%) and jaundice (6.3%) were among GIV. None complained of hematemesis or HCC.
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