A new synthesis of 2'-deoxy-2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil (13, L-FMAU) was achieved in 10 steps from L-arabinose.

A new synthesis of (-)-DAPD, suitable for large scale development, is described.

Nucleic acids U 0700Synthesis of (-)-DAPD. -A novel synthesis of (-)-DAPD (XI), a potent and selective inhibitor of HIV and HBV replication, suitable for the large scale preparation is reported involving the resolution of lactone (V) by chiral chromatography. The pure β-anomer of nucleoside (IX) slowly crystallizes from a MeOH solution of an initially formed 2:1 mixture of β:α anomers. -(SZNAIDMAN*, M. L.; DU, J.; PESYAN, A.; CLEARY, D. G.; HURLEY, K. P.; WALIGORA, F.; ALMOND, M. R.; Nucleosides,

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