ABSTRACT… Objectives:To determine diagnostic accuracy of spot urine Protein to creatinine ratio for detection of diabetic nephropathy taking 24-hour urinary protein as gold standard. Study Design: cross sectional. Settings: Medical and Radiology department of Allied hospital Faisalabad. Duration: 12-12-2013 to 12-06-2014. Sample size: 134. Material & Methods: It was a cross-sectional study done in Medical Unit I, Allied Hospital Faisalabad. 134 patients with suspicion of diabetic nephropathy were included. 24-hour urine sample collected by instructing patients to begin collection immediately after completion of first voiding in morning and to collect all urine into same container having 5mL of 10% thymol in iso-propanol as a preservative for 24-hours. This was thoroughly mixed, 2mL was taken for evaluation of proteins. P.C ratio was calculated by dividing Urinary Protein concentration by Urinary Creatinine concentration. Results: The mean age of patients was noted as 55.11±6.79 years. There were 62.7% male and 37.3% female patients. Mean PC ratio of the patients was noted as 0.21±0.07. Sensitivity of PC ratio was noted as 95.2%, whereas specificity was 76.5%, PPV 86.8%, NPV 90.7% with diagnostic accuracy of 88.1%. Conclusion: The study results showed that PC ratio is sensitive enough to diagnose diabetic nephropathy instead of 24-hour urinary protein. Article Citation: Bukhari H, Shaukat A, Mahes AH. Diabetic nephropathy; protein to creatinine ratio as a cost effective diagnostic tool for detection. Professional Med J 2016;23(3):302-306.
Objectives: To determine diagnostic accuracy of spot urine Protein to creatinineratio for detection of diabetic nephropathy taking 24-hour urinary protein as gold standard.Study Design: cross sectional. Settings: Medical and Radiology department of Allied hospitalFaisalabad. Duration: 12-12-2013 to 12-06-2014. Sample size: 134. Material & Methods: Itwas a cross-sectional study done in Medical Unit I, Allied Hospital Faisalabad. 134 patients withsuspicion of diabetic nephropathy were included. 24-hour urine sample collected by instructingpatients to begin collection immediately after completion of first voiding in morning and tocollect all urine into same container having 5mL of 10% thymol in iso-propanol as a preservativefor 24-hours. This was thoroughly mixed, 2mL was taken for evaluation of proteins. P.C ratiowas calculated by dividing Urinary Protein concentration by Urinary Creatinine concentration.Results: The mean age of patients was noted as 55.11±6.79 years. There were 62.7% maleand 37.3% female patients. Mean PC ratio of the patients was noted as 0.21±0.07. Sensitivityof PC ratio was noted as 95.2%, whereas specificity was 76.5%, PPV 86.8%, NPV 90.7% withdiagnostic accuracy of 88.1%. Conclusion: The study results showed that PC
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.