Tamsulosin discontinuation effectively increases dilated pupil size, a measure that has been inversely linked to IFIS incidence pre-operatively. Decreased DMR thickness in this short term likely illustrates changes aside from atrophy, such as vascular changes. Decreased anterior chamber depths suggest aqueous humor production is decreased as well.
Background: This research aims to investigate the role of Paecilomyces fungus infection in pathologies of bronchopulmonary and cardiovascular systems in patients having bronchial asthma. Methods: Histopathological study of lungs and cardiac tissues, in patients having bronchial asthma and Paecilomyces infection, were studied based on 15 autopsies: 5 women and 10 men, aged between 18 and 77 years, who died of intractable asthma attack and acute cardiovascular insufficiency. All the histological, histochemical, morphological, bacteriological and mycological examinations were performed. Paraffin sections from different tissues were stained with hematoxylin and eosin, and differential methods were used to detect fungi in the tissue.Results: Microscopic examination in the lungs revealed the following observations: vascular congestion, extension of venules and capillaries, spasm of arterioles, swelling of endothelial cells with a tendency to desquamation and increased permeability of the vascular wall with fungal cells in the perivascular space. Changes in vascular walls were characterized by a pattern of destructive and productive vasculitis at different stages of development from endovasculitis to panvasculitis resulting in sclerosis. The same type of changes was found in vascular walls of heart tissues and tissues of other organs, distinguished only at different times. Sclerosis of the vascular wall and perivascular tissue are manifestations of the inflammatory protective response of the host organism, limiting the further spread of the pathogen in the organ tissues. Conclusions: The development of combined vascular pathology of the bronchopulmonary and cardiovascular systems in bronchial asthma is triggered by hematogenic infection caused by dimorphic Paecilomyces fungi.
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